IQVIA HOLDINGS INC.

Current report (Form 8-K) · Jun 11, 2026 · Multiple disclosures including restructuring or layoffs and leadership change

Ticker

IQV

Documents

Primary topic

Restructuring or layoffs

Filed

Jun 11, 2026

Overview Analysis Documents(7)Full text Exhibits(1)

Type

EX-4.1

File

d157492dex41.htm

Document text
EX-4.1 · d157492dex41.htm EX-4.1 2 d157492dex41.htm EX-4.1 Exhibit 4.1 INDENTURE Dated as of June 11, 2026 among IQVIA Inc., as Issuer, the Guarantors party hereto and U.S. Bank Trust Company, National Association, as Trustee 4.625% SENIOR NOTES DUE 2033 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE SECTION 1.01. Definitions 1 SECTION 1.02. Other Definitions 33 SECTION 1.03. Rules of Construction 33 SECTION 1.04. Acts of Holders 34 SECTION 1.05. Limited Condition Transactions 35 ARTICLE II THE NOTES SECTION 2.01. Form and Dating; Terms 36 SECTION 2.02. Execution and Authentication 37 SECTION 2.03. Registrar, Transfer Agent and Paying Agent 38 SECTION 2.04. Paying Agent Provisions 38 SECTION 2.05. Holder Lists 39 SECTION 2.06. Transfer and Exchange 39 SECTION 2.07. Replacement Notes 47 SECTION 2.08. Outstanding Notes 48 SECTION 2.09. Treasury Notes 48 SECTION 2.10. Temporary Notes 48 SECTION 2.11. Cancellation 48 SECTION 2.12. Defaulted Interest 49 SECTION 2.13. ISIN and/or Common Code Numbers 49 ARTICLE III REDEMPTION SECTION 3.01. Notices to Trustee 49 SECTION 3.02. Selection of Notes to Be Redeemed 50 SECTION 3.03. Notice of Redemption 50 SECTION 3.04. Effect of Notice of Redemption 51 SECTION 3.05. Deposit of Redemption Price 51 SECTION 3.06. Notes Redeemed in Part 52 SECTION 3.07. Optional Redemption. 52 SECTION 3.08. Mandatory Redemption 53 ARTICLE IV COVENANTS SECTION 4.01. Payment of Notes 53 SECTION 4.02. Maintenance of Office or Agency 54 -i- Page SECTION 4.03. Reports and Other Information 54 SECTION 4.04. Compliance Certificate 56 SECTION 4.05. Stay, Extension and Usury Laws 57 SECTION 4.06. Company Existence 57 SECTION 4.07. Offer to Repurchase Upon Change of Control Triggering Event 57 SECTION 4.08. Limitation on Liens 59 SECTION 4.09. Limitation on Sale and Lease-Back Transactions 60 SECTION 4.10. Exempted Transactions 60 SECTION 4.11. Additional Subsidiary Guarantees 61 ARTICLE V SUCCESSORS SECTION 5.01. Merger, Consolidation or Sale of All or Substantially All Assets 61 SECTION 5.02. Successor Person Substituted 62 ARTICLE VI DEFAULTS AND REMEDIES SECTION 6.01. Events of Default 62 SECTION 6.02. Acceleration 64 SECTION 6.03. Other Remedies 64 SECTION 6.04. Waiver of Past Defaults 65 SECTION 6.05. Control by Majority 65 SECTION 6.06. Limitation on Suits 65 SECTION 6.07. Collection Suit by Trustee 65 SECTION 6.08. Restoration of Rights and Remedies 65 SECTION 6.09. Rights and Remedies Cumulative 66 SECTION 6.10. Delay or Omission Not Waiver 66 SECTION 6.11. Trustee May File Proofs of Claim 66 SECTION 6.12. Priorities 66 SECTION 6.13. Undertaking for Costs 67 ARTICLE VII TRUSTEE SECTION 7.01. Duties of Trustee 67 SECTION 7.02. Rights of Trustee 68 SECTION 7.03. Individual Rights of Trustee 69 SECTION 7.04. Trustee’s Disclaimer 70 SECTION 7.05. Notice of Defaults 70 SECTION 7.06. [Reserved] 70 SECTION 7.07. Compensation and Indemnity 70 SECTION 7.08. Replacement of Trustee 71 SECTION 7.09. Successor Trustee by Merger, etc. 72 SECTION 7.10. Eligibility; Disqualification 72 -ii- Page ARTICLE VIII LEGAL DEFEASANCE AND COVENANT DEFEASANCE SECTION 8.01. Option to Effect Legal Defeasance or Covenant Defeasance 72 SECTION 8.02. Legal Defeasance and Discharge 72 SECTION 8.03. Covenant Defeasance 73 SECTION 8.04. Conditions to Legal or Covenant Defeasance 73 SECTION 8.05. Deposited Money and Euro Government Obligations; Other Miscellaneous Provisions 75 SECTION 8.06. Repayment to Issuer 75 SECTION 8.07. Reinstatement 75 ARTICLE IX AMENDMENT, SUPPLEMENT AND WAIVER SECTION 9.01. Without Consent of Holders 75 SECTION 9.02. With Consent of Holders 77 SECTION 9.03. [Reserved] 78 SECTION 9.04. Revocation and Effect of Consents 78 SECTION 9.05. Notation on or Exchange of Notes 78 SECTION 9.06. Trustee to Sign Amendments, etc. 78 ARTICLE X GUARANTEES SECTION 10.01. Guarantee 79 SECTION 10.02. Limitation on Guarantor Liability 80 SECTION 10.03. Execution and Delivery 81 SECTION 10.04. Subrogation 81 SECTION 10.05. Benefits Acknowledged 81 SECTION 10.06. Release of Guarantees 81 ARTICLE XI SATISFACTION AND DISCHARGE SECTION 11.01. Satisfaction and Discharge 82 SECTION 11.02. Application of Trust Money 83 ARTICLE XII MISCELLANEOUS SECTION 12.01. [Reserved] 84 SECTION 12.02. Notices 84 SECTION 12.03. [Reserved] 85 SECTION 12.04. Certificate and Opinion as to Conditions Precedent 85 SECTION 12.05. Statements Required in Certificate or Opinion 85 -iii- Page SECTION 12.06. Rules by Trustee and Agents 86 SECTION 12.07. No Personal Liability of Directors, Officers, Employees and Stockholders 86 SECTION 12.08. Governing Law 86 SECTION 12.09. Waiver of Jury Trial 86 SECTION 12.10. Force Majeure 86 SECTION 12.11. No Adverse Interpretation of Other Agreements 86 SECTION 12.12. Successors 86 SECTION 12.13. Severability 87 SECTION 12.14. Counterpart Originals 87 SECTION 12.15. Table of Contents, Headings, etc. 87 SECTION 12.16. [Reserved] 87 SECTION 12.17. USA PATRIOT Act 87 EXHIBITS Exhibit A Form of Note Exhibit B Form of Certificate of Transfer Exhibit C Form of Certificate of Exchange Exhibit D Form of Supplemental Indenture to Be Delivered by Subsequent Guarantors -iv- INDENTURE, dated as of June 11, 2026, among IQVIA Inc., a Delaware corporation, each Guarantor (as defined herein) and U.S. Bank Trust Company, National Association, as trustee (the “Trustee”). W I T N E S S E T H WHEREAS, the Issuer (as defined herein) has duly authorized the issuance of 950,000,000 aggregate principal amount of 4.625% Senior Notes due 2033 issued on the date hereof (the “ Initial Notes ”); and WHEREAS, the Issuer and each of the Guarantors have duly authorized the execution and delivery of this Indenture (as defined herein). NOW, THEREFORE, each party hereto agrees as follows for the benefit of each other and for the equal and ratable benefit of the Holders (as defined herein). ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE SECTION 1.01. Definitions. “ 144A Global Note ” means a Global Note substantially in the form of Exhibit A attached hereto, with such applicable legends as are provided herein, and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its nominee for the accounts of Euroclear and Clearstream, issued in a denomination equal to the outstanding principal amount of the Notes sold in reliance on Rule 144A. “ Additional Notes ” means additional Notes (other than the Initial Notes) issued under this Indenture in accordance with Section 2.02 hereof, as part of the same series as the Initial Notes. “ Affiliate ” of any specified Person means any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified Person. For purposes of this definition, “ control ” (including, with correlative meanings, the terms “ controlling ,” “ controlled by ” and “ under common control with ”), as used with respect to any Person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of such Person, whether through the ownership of voting securities, by agreement or otherwise. “ Agent ” means any Registrar, co-registrar, Transfer Agent, co-transfer agent, principal Paying Agent or additional paying agent. “ Applicable Premium ” means, with respect to any Note on any Redemption Date, the greater of: (1) 1.0% of the principal amount of such Note; and (2) the excess, if any, of (a) the present value at such Redemption Date of (i) the redemption price of such Note at June 15, 2029 (such redemption price being set forth in the table appearing in Section 3.07(d) hereof), plus (ii) all required remaining scheduled interest payments due on such Note through June 15, 2029, excluding accrued but unpaid interest to the Redemption Date, computed using a discount rate equal to the Bund Rate as of such Redemption Date plus 50 basis points; over (b) the then outstanding principal amount of such Note on such Redemption Date, as calculated by the Issuer or on behalf of the Issuer by such Person as the Issuer shall designate; provided , that such calculation shall not be the duty or obligation of the Trustee. “ Applicable Procedures ” means, with respect to any transfer or exchange of or for beneficial interests in any Global Note, the rules and procedures of Euroclear and Clearstream, as applicable, that apply to such transfer or exchange. “ Attributable Indebtedness ” means, with respect to any Sale and Lease-Back Transaction, at the time of determination, the lesser of (1) the sale price of the property so leased multiplied by a fraction the numerator of which is the remaining portion of the base term of the lease included in such transaction and the denominator of which is the base term of such lease, and (2) the total obligation (discounted to the present value at the implicit interest factor, determined in accordance with GAAP, included in the rental payments) of the lessee for rental payments (other than amounts required to be paid on account of property taxes as well as maintenance, repairs, insurance, water rates and other items which do not constitute payments for property rights) during the remaining portion of the base term of the lease included in such transaction. Notwithstanding the foregoing, if such Sale and Lease-Back Transaction results in a Capitalized Lease Obligation, the amount of Indebtedness represented thereby will be determined in accordance with the definition of “Capitalized Lease Obligation.” “ August 2019 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the August 2019 Transactions. “ August 2019 Transactions ” means, collectively, (i) the issuance of the Senior 2.250% Notes due 2028, (ii) the satisfaction and discharge of the Senior 4.875% Notes and (iii) the payment of all fees and expenses associated with the foregoing. “ Bankruptcy Law ” means Title 11, U.S. Code, as amended, or any similar federal or state law for the relief of debtors. “ Board of Directors ” means, for any Person, the board of directors or other governing body of such Person or, if such Person does not have such a board of directors or other governing body and is owned or managed by a single entity, the Board of Directors of such entity, or, in either case, any committee thereof duly authorized to act on behalf of such Board of Directors. Unless otherwise provided, “Board of Directors” means the Board of Directors of the Issuer. “ Book-Entry Interest ” means a beneficial interest in a Global Note held by or through a Participant. “ Bund Rate ” means with respect to any redemption date, the greater of (x) 0% and (y) the rate per annum equal to the equivalent yield to maturity as of such redemption date of the Comparable German Bund Issue, assuming a price for the Comparable German Bund Issue (expressed as a percentage of its principal amount) equal to the Comparable German Bund Price for such redemption date, where: (a) “ Comparable German Bund Issue ” means the German Bundesanleihe security selected by any Reference German Bund Dealer as having a fixed maturity most nearly equal to the period from such redemption date to June 15, 2029, and that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of euro denominated corporate debt securities in a principal amount approximately equal to the then outstanding principal amount of the Notes and of a maturity most nearly equal to June 15, 2029; provided however , that, if the period from -2- such redemption date to June 15, 2029 is not equal to the fixed maturity of the German Bundesanleihe security selected by such Reference German Bund Dealer, the Bund Rate shall be determined by linear interpolation (calculated to the nearest one-twelfth of a year) from the yields of German Bundesanleihe securities having a fixed maturity (i) most nearly before June 15, 2029 and (ii) most nearly after June 15, 2029, in each case, for which such yields are given; provided , further , that if the period from such redemption date to June 15, 2029 is less than one year, a fixed maturity of one year shall be used; (b) “ Comparable German Bund Price ” means, with respect to any redemption date, the average of the Reference German Bund Dealer Quotations for such redemption date, after excluding the highest and lowest such Reference German Bund Dealer Quotations, or if the Issuer obtains fewer than four such Reference German Bund Dealer Quotations, the average of all such quotations; (c) “ Reference German Bund Dealer ” means any dealer of German Bundesanleihe securities appointed by the Issuer (and notified to the Trustee); and (d) “ Reference German Bund Dealer Quotations ” means, with respect to each Reference German Bund Dealer and any redemption date, the average of the bid and offered prices for the Comparable German Bund Issue (expressed in each case as a percentage of its principal amount) (as determined by the Issuer) quoted in writing to the Issuer by such Reference German Bund Dealer at 3:30 p.m. Frankfurt, Germany time on the third Business Day preceding such redemption date. “ Business Day ” means each day which is not a Legal Holiday. “ Capital Stock ” means: (1) in the case of a corporation, corporate stock or shares in the capital of such corporation; (2) in the case of an association or business entity, any and all shares, interests, participations, rights or other equivalents (however designated) of corporate stock; (3) in the case of a partnership or limited liability company, partnership or membership interests (whether general or limited); and (4) any other interest or participation that confers on a Person the right to receive a share of the profits and losses of, or distributions of assets of, the issuing Person but excluding from all of the foregoing any debt securities convertible into Capital Stock, whether or not such debt securities include any right of participation with Capital Stock. “ Capitalized Lease Obligation ” means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would at such time be required to be capitalized and reflected as a liability on a balance sheet (excluding the footnotes thereto) prepared in accordance with GAAP; provided that all obligations of any Person that would be characterized as operating lease obligations in accordance with GAAP without giving effect to Accounting Standards Codification Topic No. 842, Leases (whether or not such operating lease obligations were in effect on the Issue Date) shall be accounted for as operating lease obligations (and not as Capitalized Lease Obligations or Indebtedness) for purposes of this Indenture regardless of the effectiveness of Accounting Standards Codification Topic No. 842, Leases , or any other change in GAAP following the Issue Date that would otherwise require such obligations to be recharacterized (on a prospective or retroactive basis or otherwise) as Capitalized Lease Obligations. -3- “ Capitalized Software Expenditures ” means, for any period, the aggregate of all expenditures (whether paid in cash or accrued as liabilities) by a Person and its Restricted Subsidiaries during such period in respect of licensed or purchased software or internally developed software and software enhancements that, in conformity with GAAP, are or are required to be reflected as capitalized costs on the consolidated balance sheet of a Person and its Restricted Subsidiaries. “ Cash Management Services ” means any agreement or arrangement to provide cash management services, including treasury, depository, overdraft, credit card processing or credit or debit card, purchase card, electronic funds transfer (including automated clearing house fund transfer services) and other cash management arrangements. “ Change of Control ” means the occurrence of any of the following after the Issue Date: (1) the sale, lease, transfer, conveyance or other disposition in one or a series of related transactions (other than by merger, consolidation or amalgamation) of all or substantially all of the assets of the Issuer and its Subsidiaries, taken as a whole, to any Person; or (2) the Issuer becomes aware of (by way of a report or any other filing pursuant to Section 13(d) of the Exchange Act, proxy, vote, written notice or otherwise) the acquisition by (A) any Person or (B) Persons that are together a group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act, or any successor provision), including any such group acting for the purpose of acquiring, holding or disposing of securities (within the meaning of Rule 13d-5(b)(1) under the Exchange Act), in a single transaction or in a related series of transactions, by way of merger, amalgamation, consolidation or other business combination or purchase of beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act, or any successor provision) of 50.0% or more of the total voting power of the Voting Stock of the Issuer directly or indirectly through any of its direct or indirect parent holding companies, other than in each case, in connection with any transaction or series of transactions in which the Issuer shall become the Wholly-Owned Subsidiary of a Parent Company. “ Change of Control Triggering Event ” means the occurrence of: (1) if on the earlier of (a) the date of the first public announcement of a Change of Control or of the Issuer’s intention to effect such Change of Control and (b) the occurrence of such Change of Control, the Notes have an Investment Grade Rating from both Rating Agencies, (i) a Change of Control that is accompanied or followed by a downgrade of the Notes within the Ratings Decline Period for such Change of Control by both Rating Agencies and (ii) each Rating Agency’s rating of the Notes on any day during such Ratings Decline Period for such Change of Control is below the rating by such Rating Agency in effect immediately preceding the first public announcement of the Change of Control (or the occurrence thereof if such Change of Control occurs prior to the first public announcement thereof); provided , however , that a downgrade of the Notes by the applicable Rating Agency will not be deemed to have occurred in respect of a Change of Control (and thus will not be deemed a downgrade for purposes of this definition) if such Rating Agency making the reduction in rating does not publicly announce or confirm or inform the Issuer or the Trustee in writing at the request of the Issuer that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the Change of Control (whether or not the applicable Change of Control has occurred at the time of such downgrade) or (2) if the Notes do not have an Investment Grade Rating from both Rating Agencies, a Change of Control. No Change of Control Triggering Event will be deemed to have occurred in connection with a Change of Control until such Change of Control has been consummated. “ Clearing System Business Day ” means a weekday (Monday to Friday, inclusive) except December 25 and January 1. -4- “ Clearstream ” means Clearstream Banking, Société Anonyme, Luxembourg and its successors. “ Common Depositary ” means, with respect to the Notes issuable or issued in whole or in part in global form, a depositary common to Euroclear and Clearstream, which have initially appointed U.S. Bank Europe DAC, and any and all successors thereto appointed as Common Depositary hereunder and having become such pursuant to the applicable provision of this Indenture. “ Consolidated Depreciation and Amortization Expense ” means with respect to any Person for any period, the total amount of depreciation and amortization expense of such Person and its Restricted Subsidiaries, including, the amortization of intangible assets, deferred financing fees, debt issuance costs, commissions, fees and expenses and amortization of Capitalized Software Expenditures of such Person and its Restricted Subsidiaries for such period on a consolidated basis and otherwise determined in accordance with GAAP. “ Consolidated Interest Expense ” means, with respect to any Person for any period, without duplication, the sum of: (1) consolidated interest expense of such Person and its Restricted Subsidiaries for such period, to the extent such expense was deducted (and not added back) in computing Consolidated Net Income (including (a) amortization of original issue discount resulting from the issuance of Indebtedness at less than par, (b) all commissions, discounts and other fees and charges owed with respect to letters of credit or bankers acceptances, (c) non-cash interest payments (but excluding any non-cash interest expense attributable to the movement in the mark to market valuation of Hedging Obligations or other derivative instruments pursuant to GAAP), (d) the interest component of Capitalized Lease Obligations, and (e) net payments, if any, made (less net payments, if any, received), pursuant to interest rate Hedging Obligations with respect to Indebtedness, and excluding (q) any prepayment premium or penalty, (r) annual agency fees paid to the administrative agents and collateral agents under any Credit Facilities, (s) costs associated with obtaining Hedging Obligations and breakage costs in respect of Hedging Obligations related to interest rates, (t) any expense resulting from the discounting of any indebtedness in connection with the application of recapitalization accounting or, if applicable, purchase accounting in connection with any acquisition (or purchase of assets), (u) penalties and interest related to taxes, (v) any “additional interest” or “liquidated damages” with respect to other securities, (w) amortization or expensing of deferred financing fees, amendment and consent fees, debt issuance costs, commissions, fees and expenses, (x) any amortization or expensing of bridge, commitment and other financing fees and any other fees related to the May 2019 Transactions, the August 2019 Transactions, the June 2020 Transactions, the March 2021 Transactions, the May 2023 Transactions, the November 2023 Transactions, the June 2025 Transactions, the June 2026 Transactions or any acquisitions (or purchases of assets) after the Issue Date, (y) commissions, discounts, yield and other fees and charges (including any interest expense) related to any Qualified Securitization Facility and (z) any accretion of accrued interest on discounted liabilities (other than Indebtedness except to the extent arising from the application of purchase accounting)); plus (2) consolidated capitalized interest of such Person and its Restricted Subsidiaries for such period, whether paid or accrued; less (3) interest income of such Person and its Restricted Subsidiaries for such period. -5- For purposes of this definition, interest on a Capitalized Lease Obligation shall be deemed to accrue at an interest rate reasonably determined by such Person to be the rate of interest implicit in such Capitalized Lease Obligation in accordance with GAAP. “ Consolidated Net Income ” means, with respect to any Person for any period, the aggregate of the Net Income of such Person and its Restricted Subsidiaries for such period, on a consolidated basis, and otherwise determined in accordance with GAAP; provided , however , that, without duplication, (1) any net after-tax effect of extraordinary, non-recurring or unusual gains or losses, charges or expenses (including relating to any multi-year strategic initiatives), the May 2019 Transaction Expenses, the August 2019 Transaction Expenses, the June 2020 Transaction Expenses, the March 2021 Transaction Expenses, the May 2023 Transaction Expenses, the November 2023 Transaction Expenses, the June 2025 Transaction Expenses, the June 2026 Transaction Expenses, restructuring costs and reserves, duplicative running costs, relocation costs, expenses related to any reconstruction, decommissioning, recommissioning or reconfiguration of fixed assets for alternative uses, Public Company Costs, facility consolidation and closing costs, severance costs and expenses, one-time compensation charges, costs relating to pre-opening and opening costs for facilities, signing, retention or completion bonuses, executive recruiting costs, costs incurred in connection with any strategic initiatives, transition costs, costs incurred in connection with non-ordinary course product and intellectual property development, costs incurred in connection with acquisitions (or purchases of assets) prior to or after the Issue Date (including integration costs), other business optimization expenses (including costs and expenses relating to business optimization programs, and new systems design, retention charges, system establishment costs and implementation costs and project start-up costs), accruals and reserves, operating expenses attributable to the implementation of cost-savings initiatives, consulting fees and curtailments and modifications to pension and post-retirement employee benefit plans shall be excluded; (2) the cumulative effect of a change in accounting principles and changes as a result of the adoption or modification of accounting policies during such period whether effected through a cumulative effect adjustment or a retroactive application, in each case in accordance with GAAP, shall be excluded; (3) any net after-tax effect of gains or losses on disposal, abandonment (including asset retirement costs) or discontinuance of disposed, abandoned or discontinued operations, as applicable, shall be excluded; (4) any net after-tax effect of gains or losses (less all fees, expenses and charges relating thereto) attributable to asset dispositions or abandonments or the sale or other disposition of any Equity Interests of any Person other than in the ordinary course of business, as determined in good faith by the Issuer, shall be excluded; (5) the Net Income for such period of any Person that is an Unrestricted Subsidiary shall be excluded; provided that Consolidated Net Income of a Person shall be increased by the amount of dividends or distributions or other payments that are actually paid in cash (or to the extent converted into cash) to such Person or a Restricted Subsidiary thereof in respect of such period; (6) [reserved]; -6- (7) effects of adjustments (including the effects of such adjustments pushed down to such Person and its Restricted Subsidiaries) in such Person’s consolidated financial statements pursuant to GAAP (including in the inventory, property and equipment, software, goodwill, intangible assets, in process research and development, deferred revenue and debt line items) attributable to the application of recapitalization accounting or purchase accounting, as the case may be, in relation to any consummated acquisition or joint venture investment or the amortization or write-off or write-down of any amounts thereof, net of taxes, shall be excluded; (8) any net after-tax effect of income (loss) from the early extinguishment or conversion of (a) Indebtedness, (b) Hedging Obligations or (c) other derivative instruments shall be excluded; (9) any impairment charge or asset write-off or write-down in each case, pursuant to GAAP, and the amortization of intangibles arising pursuant to GAAP shall be excluded; (10) any equity-based or non-cash compensation charge or expense, including any such charge or expense arising from grants of stock appreciation, equity incentive programs or similar rights, stock options, restricted stock or other rights, shall be excluded; (11) any fees, expenses or charges incurred during such period, or any amortization thereof for such period, in connection with any acquisition, Investment, disposition, incurrence or repayment of Indebtedness (including such fees, expenses or charges related to the offering and issuance of the Notes, the Existing Senior Notes and the syndication and incurrence of any Credit Facilities), issuance of Equity Interests, recapitalization, refinancing transaction or amendment or modification of any debt instrument (including any amendment or other modification of the Notes, the Existing Senior Notes and other securities and any Credit Facilities) and including, in each case, any such transaction whether consummated on, after or prior to the Issue Date and any such transaction undertaken but not completed, and any charges or non-recurring merger costs incurred during such period as a result of any such transaction, in each case whether or not successful or consummated (including, for the avoidance of doubt, the effects of expensing all transaction related expenses in accordance with Accounting Standards Codification Topic No. 805, Business Combinations ), shall be excluded; (12) accruals and reserves that are established or adjusted within twelve months after the closing of any acquisition that are so required to be established as a result of such acquisition in accordance with GAAP shall be excluded; (13) any expenses, charges or losses to the extent covered by insurance or indemnity and actually reimbursed, or, so long as such Person has made a determination that there exists reasonable evidence that such amount will in fact be reimbursed by the insurer or indemnifying party and only to the extent that such amount is in fact reimbursed within 365 days of the date of the insurable or indemnifiable event (net of any amount so added back in any prior period to the extent not so reimbursed within the applicable 365-day period), shall be excluded; (14) any noncash compensation expense resulting from the application of Accounting Standards Codification Topic No. 718, Compensation — Stock Compensation or Accounting Standards Codification Topic 505-50, Equity-Based Payments to Non-Employees , shall be excluded; and -7- (15) the following items shall be excluded: (a) research and development expenses and charges to the extent expensed; and (b) earn-out and contingent consideration obligations (including to the extent accounted for as bonuses or otherwise) and adjustments thereof and purchase price adjustments. In addition, to the extent not already included in the Consolidated Net Income of such Person and its Restricted Subsidiaries, notwithstanding anything to the contrary in the foregoing, Consolidated Net Income shall include the amount of proceeds received from business interruption insurance and reimbursements of any expenses and charges that are covered by indemnification or other reimbursement provisions in connection with any acquisition, Investment or any sale, conveyance, transfer or other disposition of assets. “ Consolidated Total Debt ” means, as of any date of determination, the aggregate principal amount of Indebtedness of the Issuer and its Restricted Subsidiaries outstanding on such date, determined on a consolidated basis in accordance with GAAP (but excluding the effects of any discounting of Indebtedness resulting from the application of purchase accounting in connection with any acquisition), consisting only of Indebtedness for borrowed money, Capitalized Lease Obligations, debt obligations evidenced by bonds, notes, debentures, promissory notes or similar instruments and guarantees of Indebtedness of such types of a third Person; provided that Consolidated Total Debt shall not include Indebtedness in respect of (i) any Qualified Securitization Facility, (ii) any letter of credit, except to the extent of obligations in respect of drawn standby letters of credit which have not been reimbursed within three (3) Business Days and (iii) Hedging Obligations, except any unpaid termination payments thereunder. The U.S. dollar-equivalent principal amount of any Indebtedness denominated in a foreign currency will reflect the currency translation effects, determined in accordance with GAAP, of Hedging Obligations for currency exchange risks with respect to the applicable currency in effect on the date of determination of the U.S. dollar-equivalent principal amount of such Indebtedness. “ Contingent Obligations ” means, with respect to any Person, any obligation of such Person guaranteeing any leases, dividends or other obligations that do not constitute Indebtedness (“ primary obligations ”) of any other Person (the “ primary obligor ”) in any manner, whether directly or indirectly, including any obligation of such Person, whether or not contingent: (1) to purchase any such primary obligation or any property constituting direct or indirect security therefor; (2) to advance or supply funds (a) for the purchase or payment of any such primary obligation, or (b) to maintain working capital or equity capital of the primary obligor or otherwise to maintain the net worth or solvency of the primary obligor; or (3) to purchase property, securities or services primarily for the purpose of assuring the owner of any such primary obligation of the ability of the primary obligor to make payment of such primary obligation against loss in respect thereof. -8- “ Controlled Investment Affiliate ” means, as to any Person, any other Person which directly or indirectly is in control of, is controlled by, or is under common control with such Person and is organized by such Person (or any Person controlling such Person) primarily for making direct or indirect equity or debt investments in the Issuer and/or other companies. “ Corporate Trust Office of the Trustee ” shall be at the address of the Trustee specified in Section 12.02 hereof or such other address as to which the Trustee may give notice to the Holders and the Issuer. “ Credit Facilities ” means, with respect to the Issuer or any of its Restricted Subsidiaries, one or more debt facilities, including the Senior Credit Facilities or other financing arrangements (including commercial paper facilities or indentures) providing for revolving credit loans, term loans, letters of credit or other long-term indebtedness, including any notes, mortgages, guarantees, collateral documents, instruments and agreements executed in connection therewith, and any amendments, supplements, modifications, extensions, renewals, restatements or refundings thereof, in whole or in part, and any indentures or credit facilities or commercial paper facilities that replace, refund, supplement or refinance any part of the loans, notes, other credit facilities or commitments thereunder, including any such replacement, refunding, supplemental or refinancing facility, arrangement or indenture that increases the amount permitted to be borrowed or issued thereunder or alters the maturity thereof or adds Restricted Subsidiaries as additional borrowers or guarantors thereunder and whether by the same or any other agent, trustee, lender or group of lenders or holders. “ Default ” means any event that is, or with the passage of time or the giving of notice or both would be, an Event of Default. “ Definitive Note ” means a certificated Note registered in the name of the Holder thereof and issued in accordance with Section 2.06(c) hereof, substantially in the form of Exhibit A attached hereto, except that such Note shall not bear the Global Note Legend and shall not have the “Schedule of Exchanges of Interests in the Global Note” attached thereto. “ Disqualified Stock ” means, with respect to any Person, any Capital Stock of such Person which, by its terms, or by the terms of any security into which it is convertible or for which it is redeemable or exchangeable, or upon the happening of any event, matures or is mandatorily redeemable (other than for any Qualified Equity Interests or solely as a result of a change of control, asset sale, casualty, condemnation or eminent domain) pursuant to a sinking fund obligation or otherwise, or is redeemable at the option of the holder thereof (other than for any Qualified Equity Interests or solely as a result of a change of control, asset sale, casualty, condemnation or eminent domain), in whole or in part, in each case prior to the date 91 days after the earlier of the maturity date of the Notes or the date the Notes are no longer outstanding; provided , that if such Capital Stock is issued to any plan for the benefit of future, current or former employees, directors, officers, members of management, consultants or independent contractors (or their respective Controlled Investment Affiliates or Immediate Family Members or any permitted transferee thereof) of the Issuer or its Subsidiaries or any direct or indirect parent company of the Issuer or by any such plan to such employees, directors, officers, members of management, consultants or independent contractors (or their respective Controlled Investment Affiliates or Immediate Family Members or any permitted transferee thereof), such Capital Stock shall not constitute Disqualified Stock solely because it may be redeemable or subject to repurchase by the Issuer or its Subsidiaries pursuant to any such plan or agreement or in order to satisfy applicable statutory or regulatory obligations or as a result of such employee’s, director’s, officer’s, management member’s, consultant’s or independent contractor’s termination, death or disability; provided , further , that any Capital Stock held by any future, current or former employee, director, officer, member of management, consultant or independent contractor (or their respective Controlled Investment Affiliates or Immediate -9- Family Members or any permitted transferee thereof) of the Issuer, any of its Subsidiaries, any of its direct or indirect parent companies or any other entity in which the Issuer or a Restricted Subsidiary has an Investment and is designated in good faith as an “affiliate” by the Board of Directors (or the compensation committee thereof), in each case pursuant to any stock subscription or shareholders’ agreement, management equity plan or stock option plan or any other management or employee benefit plan or agreement shall not constitute Disqualified Stock solely because it may be required to be repurchased by the Issuer or its Subsidiaries or in order to satisfy applicable statutory or regulatory obligations or as a result of such employee’s, director’s, officer’s, management member’s, consultant’s or independent contractor’s termination, death or disability. “ EBITDA ” means, with respect to any Person for any period, the Consolidated Net Income of such Person and its Restricted Subsidiaries for such period: (1) increased (without duplication) by the following, in each case (other than in the case of clauses (g) and (j)) to the extent deducted (and not added back) in determining Consolidated Net Income for such period: (a) provision for taxes based on income or profits or capital, including federal, state, franchise, property, excise and similar taxes and foreign withholding taxes (including any future taxes or other levies which replace or are intended to be in lieu of such taxes and any penalties and interest related to such taxes or arising from tax examinations) and the net tax expense associated with any adjustments made pursuant to clauses (1) through (15) of the definition of “Consolidated Net Income”; plus (b) Fixed Charges for such period (including (x) net losses under Hedging Obligations or other derivative instruments entered into for the purpose of hedging interest rate risk, (y) bank fees and other deferred financing fees, and (z) costs of surety bonds in connection with financing activities, plus amounts excluded from Consolidated Interest Expense as set forth in clauses (1)(q) through (z) in the definition thereof); plus (c) Consolidated Depreciation and Amortization Expense for such period; plus (d) any other non-cash charges, including any write-offs or write-downs reducing Consolidated Net Income for such period ( provided that if any such non-cash charges represent an accrual or reserve for potential cash items in any future period, (A) the Issuer may determine not to add back such non-cash charge in the current period and (B) to the extent the Issuer does decide to add back such non-cash charge, the cash payment in respect thereof in such future period shall be subtracted from EBITDA to such extent, and excluding amortization of a prepaid cash item that was paid in a prior period); plus (e) the amount of any reductions in arriving at Net Income resulting from the application of Accounting Standards Codification Topic No. 810, Consolidation ; plus (f) the amount of management, monitoring, consulting, transaction, advisory and other fees (including termination fees) and indemnities and expenses paid or accrued in such period to the Persons with an equity interest in the Issuer or its direct or indirect parent companies; plus -10- (g) the amount of “run rate” net cost savings, synergies and operating expense reductions (other than any of the foregoing related to Specified Transactions) projected by the Issuer in good faith to result from actions taken, committed to be taken or with respect to which substantial steps have been taken or are expected in good faith to be taken no later than twenty-four (24) months after the end of such period (calculated on a pro forma basis as though such cost savings, operating expense reductions and synergies had been realized on the first day of the period for which EBITDA is being determined and if such cost savings, operating expense reductions and synergies were realized during the entirety of such period), net of the amount of actual benefits realized during such period from such actions; provided , that such cost savings, operating expense reductions and synergies are reasonably identifiable and factually supportable (it is understood and agreed that “run-rate” means the full recurring benefit for a period that is associated with any action taken, committed to be taken or with respect to which substantial steps have been taken or are expected to be taken); plus (h) the amount of loss on sale of receivables, Securitization Assets and related assets to any Securitization Subsidiary in connection with a Qualified Securitization Facility; plus (i) any costs or expense incurred pursuant to any management equity plan, stock option plan or any other management or employee benefit plan, agreement or any stock subscription or shareholder agreement, to the extent that such costs or expenses are funded with cash proceeds contributed to the capital of such Person or net cash proceeds of an issuance of Equity Interests of such Person (other than Disqualified Stock); plus (j) cash receipts (or any netting arrangements resulting in reduced cash expenditures) not representing EBITDA or Consolidated Net Income in any period to the extent non-cash gains relating to such income were deducted in the calculation of EBITDA pursuant to clause (2) below for any previous period and not added back; plus (k) any net loss from disposed, abandoned or discontinued operations (excluding held-for-sale discontinued operations until actually disposed of); plus (l) Specified Legal Expenses; and (2) decreased (without duplication) by the following, in each case to the extent included in determining Consolidated Net Income for such period: (a) non-cash gains increasing Consolidated Net Income for such period, excluding any non-cash gains that represent the reversal of an accrual or reserve for any anticipated cash charges in any prior period (other than any such accrual or reserve that has been added back to Consolidated Net Income in calculating EBITDA in accordance with this definition); plus (b) any non-cash gains with respect to cash actually received in a prior period unless such cash did not increase EBITDA in such prior period; plus (c) any net income from disposed, abandoned or discontinued operations (excluding held-for-sale discontinued operations until actually disposed of); and -11- (3) increased (by losses) or decreased (by gains), as applicable, by the following, without duplication, in each case, except for the adjustments set forth in the proviso to this clause (3), to the extent included in computing Consolidated Net Income for such period: (a) any net gain or loss resulting in such period from Hedging Obligations and the application of Accounting Standards Codification Topic No. 815, Derivatives and Hedging ; (b) any net gain or loss resulting in such period from a sale of Securitization Assets to a Securitization Subsidiary in connection with a Qualified Securitization Facility; (c) any realized or unrealized gains or losses in such period from (i) balance sheet currency translation, (ii) currency translation of assets or liabilities that are not denominated in the functional currency of a Person into the functional currency of that Person and (iii) Hedging Obligations that are designated by a Person as a hedge of an asset or liability in clause (c)(i) or (ii); and (d) any adjustments resulting from the application of Accounting Standards Codification Topic No. 460, Guarantees , or any comparable regulation; provided that, notwithstanding the foregoing, EBITDA shall include (without duplication) (i) any net realized gain or loss from any Hedging Obligations accounted for as cash flow hedges of intercompany royalties and (ii) any net realized gain or loss from any Hedging Obligations that are designated by the Issuer as EBITDA hedges, except to the extent any such Hedging Obligations are terminated by such Person prior to their scheduled maturity. “ Equity Interests ” means Capital Stock and all warrants, options or other rights to acquire Capital Stock, but excluding any debt security that is convertible into, or exchangeable for, Capital Stock. “ Equity Offering ” means any public or private sale of common stock or Preferred Stock of the Issuer or any of its direct or indirect parent companies (excluding Disqualified Stock), other than: (1) public offerings with respect to the Issuer’s or any direct or indirect parent company’s common stock registered on Form S-4 or Form S-8; or (2) issuances to any Subsidiary of the Issuer. “ Euro Government Obligations ” means any security that is (1) a direct obligation of any country that is a member of the European Monetary Union whose long-term debt is rated ‘‘A-1’’ or higher by Moody’s or ‘‘A+’’ or higher by S&P or the equivalent rating category of another internationally recognized rating agency on the date of this Indenture, for the payment of which the full faith and credit of such country is pledged or (2) an obligation of a person controlled or supervised by and acting as an agency or instrumentality of any such country the payment of which is unconditionally guaranteed as a full faith and credit obligation by such country, which, in either case under the preceding clauses (1) and (2), is not callable or redeemable at the option of the issuer thereof and shall also include a depository receipt issued by a bank (as defined in Section 3(a)(2) of the Securities Act), as custodian with respect to any such Euro Government Obligations or a specific payment of principal of or interest on any such Euro Government Obligations held by such custodian for the account of the holder of such depository receipt; provided that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder of such depository receipt from any amount received by the custodian in respect of the Euro Government Obligations or the specific payment of principal of or interest on the Euro Government Obligations evidenced by such depository receipt. -12- “ Euroclear ” means Euroclear Bank SA/NV, as operator of the Euroclear system, and its successors. “ Euros ” or “ ” means the currency introduced at the start of the third stage of the European economic and monetary union pursuant to the Treaty establishing the European Community, as amended by the Treaty on European Union. “ Exchange Act ” means the Securities Exchange Act of 1934, as amended, and the rules and regulations of the SEC promulgated thereunder. “ Existing Senior Notes ” means, collectively, the Senior 2.250% Notes due 2028, the Senior 2.250% Notes due 2029, the Senior 2.875% Notes due 2028, the Senior 5.000% Notes due 2026, the Senior 5.000% Notes due 2027, the Senior Secured 5.700% Notes due 2028, the Senior Secured 6.250% Notes due 2029, the Senior 6.500% Notes due 2030 and the Senior 6.250% Notes due 2032. “ fair market value ” means, with respect to any asset or liability, the fair market value of such asset or liability as determined by the Issuer in good faith. “ Financial Officer ” means the Chief Financial Officer, the Treasurer or other financial officer of the Issuer, as applicable. “ Fixed Charges ” means, with respect to any Person for any period, the sum of, without duplication: (1) Consolidated Interest Expense of such Person for such period; (2) all cash dividends or other distributions paid (excluding items eliminated in consolidation) on any series of Preferred Stock during such period; and (3) all cash dividends or other distributions paid (excluding items eliminated in consolidation) on any series of Disqualified Stock during such period. “ Foreign Subsidiary ” means, with respect to any Person, (a) any Restricted Subsidiary of such Person that is not organized or existing under the laws of the United States, any state thereof or the District of Columbia and any Restricted Subsidiary of such Foreign Subsidiary and (b) any Restricted Subsidiary that is treated as a disregarded entity for United States federal income tax purposes and substantially all of whose assets consist of Equity Interests and/or Indebtedness of one or more Foreign Subsidiaries and any Restricted Subsidiary of such Foreign Subsidiary. “ Funded Debt ” means any Indebtedness for money borrowed (other than in connection with a Qualified Securitization Facility), whether created, issued, incurred, assumed or guaranteed, that would, in accordance with GAAP, be classified as long-term debt, but in any event including all Indebtedness for money borrowed, whether secured or unsecured, maturing more than one year, or extendible at the option of the obligor to a date more than one year, after the date of determination thereof (excluding any amount thereof included in current liabilities other than Indebtedness incurred under a revolving credit facility). -13- “ GAAP ” means (1) generally accepted accounting principles in the United States of America which are in effect on the Issue Date but without giving effect to Accounting Standards Codification Topic No. 842, Leases or (2) after the Issue Date, if elected by the Issuer by written notice to the Trustee in connection with the delivery of financial statements and information, the accounting standards and interpretations (“ IFRS ”) adopted by the International Accounting Standard Board, as in effect on the first date of the period for which the Issuer is making such election; provided , that (a) any such election once made shall be irrevocable, (b) all financial statements and reports required to be provided after such election pursuant to this Indenture shall be prepared on the basis of IFRS, (c) from and after such election, all ratios, computations and other determinations based on GAAP contained in this Indenture shall be computed in conformity with IFRS and (d) in connection with the delivery of financial statements (x) for any of its first three financial quarters of any financial year, it shall restate its consolidated interim financial statements for such interim financial period and the comparable period in the prior year to the extent previously prepared in accordance with GAAP as in effect on the Issue Date and (y) for delivery of audited annual financial information, it shall provide consolidated historical financial statements prepared in accordance with IFRS for the prior most recent fiscal year to the extent previously prepared in accordance with GAAP as in effect on the Issue Date. “ Global Note Legend ” means the legend set forth in Section 2.06(g)(ii) hereof, which is required to be placed on all Global Notes issued under this Indenture. “ Global Notes ” means, individually and collectively, a 144A Global Note and a Regulation S Global Note. “ guarantee ” means a guarantee (other than by endorsement of negotiable instruments for collection in the ordinary course of business or consistent with industry practice), direct or indirect, in any manner (including letters of credit and reimbursement agreements in respect thereof), of all or any part of any Indebtedness or other obligations. “ Guarantee ” means the guarantee by any Guarantor of the Issuer’s Obligations under this Indenture and the Notes. “ Guarantor ” means each Restricted Subsidiary of the Issuer, if any, that Guarantees the Notes in accordance with the terms of this Indenture. “ Hedging Obligations ” means, with respect to any Person, the obligations of such Person under any interest rate swap agreement, interest rate cap agreement, interest rate collar agreement, commodity swap agreement, commodity cap agreement, commodity collar agreement, foreign exchange contract, currency swap agreement or similar agreement providing for the transfer, modification or mitigation of interest rate, currency or commodity risks either generally or under specific contingencies. “ Holder ” means the Person in whose name a Note is registered on the Registrar’s books. “ Holdings ” means IQVIA Holdings Inc., a Delaware corporation. “ Immediate Family Members ” means with respect to any individual, such individual’s child, stepchild, grandchild or more remote descendant, parent, stepparent, grandparent, spouse, former spouse, qualified domestic partner, sibling, mother-in-law, father-in-law, son-in-law and daughter-in-law (including adoptive relationships) and any trust, partnership or other bona fide estate-planning vehicle the only beneficiaries of which are any of the foregoing individuals or any private foundation or fund that is controlled by any of the foregoing individuals or any donor-advised fund of which any such individual is the donor. -14- “ Indebtedness ” means, with respect to any Person, without duplication: (1) any indebtedness (including principal and premium) of such Person, whether or not contingent: (a) in respect of borrowed money; (b) evidenced by bonds, notes, debentures or similar instruments or letters of credit or bankers’ acceptances (or, without duplication, reimbursement agreements in respect thereof); (c) representing the balance deferred and unpaid of the purchase price of any property (including Capitalized Lease Obligations) due more than twelve months after such property is acquired, except (i) any such balance that constitutes an obligation in respect of a commercial letter of credit, a trade payable or similar obligation to a trade creditor, in each case accrued in the ordinary course of business or consistent with industry practice, (ii) any earn-out obligations until such obligation becomes a liability on the balance sheet of such Person in accordance with GAAP and is not paid within thirty (30) days after becoming due and payable or (iii) accruals for payroll and other liabilities accrued in the ordinary course of business; or (d) representing the net obligations under any Hedging Obligations; if and to the extent that any of the foregoing Indebtedness (other than obligations in respect of letters of credit and Hedging Obligations) would appear as a liability upon a balance sheet (excluding the footnotes thereto) of such Person prepared in accordance with GAAP; provided , that Indebtedness of any direct or indirect parent of the Issuer appearing upon the balance sheet of the Issuer solely by reason of push-down accounting under GAAP shall be excluded; (2) to the extent not otherwise included, any obligation by such Person to be liable for, or to pay, as obligor, guarantor or otherwise, on the obligations of the type referred to in clause (1) of a third Person (whether or not such items would appear upon the balance sheet of such obligor or guarantor), other than by endorsement of negotiable instruments for collection in the ordinary course of business or consistent with industry practice; and (3) to the extent not otherwise included, the obligations of the type referred to in clause (1) of a third Person secured by a Lien on any asset owned by such first Person, whether or not such Indebtedness is assumed by such first Person; provided that the amount of such Indebtedness that is not recourse to the Issuer or any Restricted Subsidiary except with respect to such specific asset will be the lesser of (i) the fair market value of such asset at such date of determination, and (ii) the amount of such Indebtedness of such other Person; provided , that notwithstanding the foregoing, Indebtedness shall be deemed not to include (a) Contingent Obligations incurred in the ordinary course of business or consistent with industry practice, (b) reimbursement obligations under commercial letters of credit ( provided that unreimbursed amounts under letters of credit shall be counted as Indebtedness three (3) Business Days after such amount is drawn), (c) obligations under or in respect of Qualified Securitization Facilities; provided , further , that Indebtedness shall be calculated without giving effect to the effects of Accounting Standards Codification Topic No. 815, Derivatives and Hedging , and related interpretations to the extent such effects would otherwise increase or decrease an amount of Indebtedness for any purpose under this Indenture as a result of accounting for any embedded derivatives created by the terms of such Indebtedness or (d) deferred or prepaid revenues. For the avoidance of doubt, Indebtedness shall not include royalty payments. -15- “ Indenture ” means this Indenture, as amended, supplemented or otherwise modified from time to time. “ Indirect Participant ” means a Person who holds a beneficial interest in a Global Note through a Participant. “ Initial Purchasers ” means J.P. Morgan Securities plc, Barclays Bank PLC, Merrill Lynch International, Citigroup Global Markets Limited, Goldman Sachs & Co. LLC, HSBC Securities (USA) Inc., MUFG Securities EMEA plc, PNC Capital Markets LLC, TD Securities (USA) LLC, Truist Securities, Inc., Wells Fargo Securities International Limited, BNP Paribas, Fifth Third Securities, Inc., ING Financial Markets LLC, RBC Europe Limited, Regions Securities LLC and Huntington Securities, Inc. “ Interest Payment Date ” means June 15 and December 15 of each year to stated maturity, beginning December 15, 2026. “ Investment Grade Rating ” means a rating equal to or higher than Baa3 (or the equivalent) by Moody’s and BBB- (or the equivalent) by S&P, or an equivalent rating by any other Rating Agency selected by the Issuer. “ Investments ” means, with respect to any Person, all investments by such Person in other Persons (including Affiliates) in the form of loans (including guarantees), advances or capital contributions (excluding accounts receivable, credit card and debit card receivables, trade credit, advances to customers, commission, travel and similar advances to employees, directors, officers, members of management, manufacturers, consultants and independent contractors, in each case made in the ordinary course of business or consistent with industry practice), and purchases or other acquisitions for consideration of Indebtedness, Equity Interests or other securities issued by any other Person. “ Issue Date ” means June 11, 2026. “ Issuer ” means IQVIA Inc. and its successors. “ Issuer’s Order ” means a written request or order signed on behalf of the Issuer by an Officer, who must be the principal executive officer, the principal financial officer, the treasurer or the principal accounting officer of the Issuer, and delivered to the Trustee. “ June 2020 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the June 2020 Transactions. “ June 2020 Transactions ” means, collectively, (i) the issuance of the Senior 2.875% Notes due 2028, (ii) the satisfaction and discharge of the Senior 3.500% Notes and (iii) the payment of all fees and expenses associated with the foregoing. “ June 2025 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the June 2025 Transactions. -16- “ June 2025 Transactions ” means, collectively, (i) the issuance of Senior 6.250% Notes due 2032, (ii) the prepayment of $1,700.0 million of revolving loans under the Senior Credit Facilities and (iii) the payment of all fees and expenses associated with the foregoing. “ June 2026 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the June 2026 Transactions. “ June 2026 Transactions ” means, collectively, (i) the issuance of the Notes on the Issue Date and (ii) the payment of all fees and expenses associated with the foregoing. “ LCT Test Date ” means the date specified in the LCT Election; provided , that (a) with respect to any prepayment of Indebtedness, such date shall be the date of the irrevocable prepayment notice and (b) with respect to all other Limited Condition Transactions, such date shall be the date of the definitive agreements for such Limited Condition Transaction. “ Legal Holiday ” means a Saturday, a Sunday or a day on which commercial banking institutions are not required to be open in the State of New York, London or at the place of payment. If a payment date is on a Legal Holiday, payment will be made on the next succeeding day that is not a Legal Holiday and no interest shall accrue in, or be payable in respect of, the intervening period. “ Lien ” means, with respect to any asset, any mortgage, lien (statutory or otherwise), pledge, hypothecation, charge, security interest or encumbrance of any kind in respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law, including any conditional sale or other title retention agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest in and any filing of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction; provided , that in no event shall an operating lease be deemed to constitute a Lien. “ Limited Condition Transaction ” means any (a) acquisition, Investment or Sale and Lease-Back Transaction by the Issuer or one or more of its Restricted Subsidiaries whose consummation is not conditioned on the availability of, or on obtaining, third-party financing and (b) redemption, repurchase, defeasance, satisfaction and discharge or repayment of Indebtedness requiring irrevocable notice in advance of such redemption, repurchase, defeasance, satisfaction and discharge or repayment. “ March 2021 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the March 2021 Transactions. “ March 2021 Transactions ” means, collectively, (i) the issuance of the Senior 1.750% Notes and the Senior 2.250% Notes due 2029, (ii) the satisfaction and discharge of the Senior 3.250% Notes and (iii) the payment of all fees and expenses associated with the foregoing. “ May 2019 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the May 2019 Transactions. “ May 2019 Transactions ” means, collectively, (i) the issuance of the 5.000% Senior Notes due 2027 and (ii) the payment of all fees and expenses associated with the foregoing. “ May 2023 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted Subsidiary in connection with the May 2023 Transactions. -17- “ May 2023 Transactions ” means, collectively, (i) the issuance of the Senior 6.500% Notes due 2030, (ii) the issuance of the Senior Secured 5.700% Notes due 2028 and (iii) the payment of all fees and expenses associated with the foregoing. “ Moody’s ” means Moody’s Investors Service, Inc. and any successor to its rating agency business. “ Net Income ” means, with respect to any Person, the net income (loss) of such Person, determined in accordance with GAAP and before any reduction in respect of Preferred Stock dividends. “ Net Proceeds ” means the aggregate cash proceeds received by the Issuer or any of its Restricted Subsidiaries in respect of any Sale and Lease-Back Transaction, net of the costs relating to such Sale and Lease-Back Transaction, including legal, accounting and investment banking fees, payments made in order to obtain a necessary consent or required by applicable law, and brokerage and sales commissions, any relocation expenses incurred as a result thereof, other fees and expenses, including title and recordation expenses, taxes paid or payable as a result thereof or any transactions occurring or deemed to occur to effectuate a payment under this Indenture (after taking into account any available tax credits or deductions and any tax sharing arrangements), amounts required to be applied to the repayment of principal, premium, if any, and interest on Indebtedness (other than Subordinated Indebtedness) or amounts required to be applied to the repayments of Indebtedness secured by a Lien on such assets and required to be paid as a result of such transaction and any deduction of appropriate amounts to be provided by the Issuer or any of its Restricted Subsidiaries as a reserve in accordance with GAAP against any liabilities associated with the Sale and Lease-Back Transaction and retained by the Issuer or any of its Restricted Subsidiaries after such Sale and Lease-Back Transaction, including any indemnification obligations associated with such transaction. “ Non-U.S. Person ” means a Person who is not a U.S. Person. “ Notes ” means, collectively, the Initial Notes and any Additional Notes. “ Notes Custodian ” means the custodian with respect to the Global Notes (as appointed by the Common Depositary) or any successor person thereto, and shall initially be U.S. Bank Europe DAC. “ November 2023 Transaction Expenses ” means any fees, costs or expenses incurred and paid by the Issuer or any Restricted Subsidiary in connection with November 2023 Transactions. “ November 2023 Transactions ” means, collectively, (i) the issuance of Senior Secured 6.250% Notes due 2029 and (ii) the payment of all fees and expenses associated with the foregoing. “ Obligations ” means any principal, interest, fees and expenses (including any such interest, fees and expenses accruing on or subsequent to the filing of a petition in bankruptcy, reorganization or similar proceeding, whether or not such interest, fees or expenses is an allowed or allowable claim under applicable state, federal or foreign law), premium, penalties, indemnifications, reimbursements (including reimbursement obligations with respect to letters of credit and banker’s acceptances), damages and other liabilities, and guarantees of payment of such principal, interest, penalties, fees, indemnifications, reimbursements, damages and other liabilities, payable under the documentation governing any Indebtedness. “ Offering Memorandum ” means the confidential offering memorandum, dated June 4, 2026, relating to the sale of the Initial Notes. -18- “ Officer ” means the Chairman of the Board of Directors, the Chief Executive Officer, the Chief Financial Officer, the Chief Operating Officer, the President, any Executive Vice President, Senior Vice President or Vice President, the Treasurer or the Secretary of any Person. Unless otherwise indicated, Officer shall refer to an Officer of the Issuer. “ Officer’s Certificate ” means a certificate signed on behalf of a Person by an Officer of such Person that meets the requirements set forth in this Indenture. “ Opinion of Counsel ” means a written opinion from legal counsel who is acceptable to the Trustee. The counsel may be an employee of or counsel to the Issuer or the Trustee. “ Parent Company ” means any Person so long as such Person directly or indirectly holds 100.0% of the total voting power of the Capital Stock of the Issuer, and at the time such Person acquired such voting power, no Person and no Persons that are together a group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act or any successor provision), including any such group acting for the purpose of acquiring, holding or disposing of securities (within the meaning of Rule 13d-5(b)(1) under the Exchange Act), shall have beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act, or any successor provision), directly or indirectly, of 50.0% or more of the total voting power of the Voting Stock of such Person. “ Participant ” means, with respect to Euroclear or Clearstream, a Person who has an account with Euroclear or Clearstream, respectively. “ Permitted Liens ” means, with respect to any Person: (1) pledges or deposits by such Person under workmen’s compensation laws, unemployment insurance, health, disability or employee benefits, other social security laws or similar legislation or regulations or other insurance-related obligations (including, but not limited to, in respect of deductibles, self-insured retention amounts and premiums and adjustments thereto) or indemnification obligations of (including obligations in respect of letters of credit or bank guarantees for the benefit of) insurance carriers providing property, casualty or liability insurance, or good faith deposits in connection with bids, tenders, contracts (other than for the payment of Indebtedness) or leases to which such Person is a party, or deposits to secure public or statutory obligations of such Person or deposits of cash or U.S. government bonds to secure surety or appeal bonds to which such Person is a party, or deposits as security for contested taxes or import duties or for the payment of rent, in each case incurred in the ordinary course of business; (2) landlords’, carriers’, warehousemen’s, materialsmen’s, repairmen’s, construction and mechanics’ Liens, in each case arising in the ordinary course of business and (i) for sums not yet overdue for a period of more than 60 days or, if more than 60 days overdue, are unfiled and no other action has been taken to enforce such Liens, (ii) being contested in good faith by appropriate actions or other Liens arising out of judgments or awards against such Person with respect to which such Person shall then be proceeding with an appeal or other proceedings for review if adequate reserves with respect thereto are maintained on the books of such Person in accordance with GAAP or (iii) the nonpayment of which in the aggregate would not reasonably be expected to have a material adverse effect on the Issuer or its Restricted Subsidiaries; (3) Liens for taxes, assessments or other governmental charges not yet overdue for a period of more than 30 days or not yet payable or subject to penalties for nonpayment or which are being contested in good faith by appropriate actions, if adequate reserves with respect thereto are maintained on the books of such Person in accordance with GAAP; -19- (4) Liens in favor of issuers of performance, surety, bid, indemnity, warranty, release, appeal or similar bonds, instruments or obligations or with respect to regulatory requirements or letters of credit or bankers acceptance issued, and completion guarantees provided for, in each case, issued pursuant to the request of and for the account of such Person in the ordinary course of its business or consistent with past practice or industry practice; (5) survey exceptions, encumbrances, easements or reservations of, or rights of others for, licenses, rights-of-way, servitudes, sewers, electric lines, telegraph, telephone and cable television lines and other similar purposes, or zoning, building codes or other restrictions (including minor defects or irregularities in title and similar encumbrances) as to the use of real properties or Liens incidental to the conduct of the business of such Person or to the ownership of its properties which were not incurred in connection with Indebtedness and which do not in the aggregate materially impair their use in the operation of the business of such Person and exceptions on title policies insuring liens granted on Mortgaged Properties (as defined in the Senior Credit Facilities); (6) Liens securing Capitalized Lease Obligations and purchase money obligations (including in respect of mortgage, industrial revenue bond, industrial development bond and similar financings) and otherwise securing all or any part of the purchase price of property acquired or cost of construction of property or cost of additions, substantial repairs, alternations or improvements of property, if the Indebtedness and the related Liens are incurred within 18 months of the later of such acquisition of property or completion of construction or addition, repairs, alterations or improvements, as the case may be; (7) Liens existing, or provided for under binding contracts existing, on the Issue Date; (8) Liens on property or shares of stock or other assets of a Person at the time such Person becomes a Subsidiary; provided , that such Liens are not created or incurred in connection with, or in contemplation of, such other Person becoming such a Subsidiary; provided , further , that such Liens are limited to all or part of the same property or assets (plus improvements, accessions, proceeds or dividends or distributions in respect thereof and after-acquired property) that secured the obligations to which such Liens relate; (9) Liens on property or other assets at the time the Issuer or a Restricted Subsidiary acquired the property or such other assets, including any acquisition by means of a merger, amalgamation or consolidation with or into the Issuer or any of its Restricted Subsidiaries; provided , that such Liens are not created or incurred in connection with, or in contemplation of, such acquisition, amalgamation, merger or consolidation; provided , further , that such Liens are limited to all or part of the same property or assets (plus improvements, accessions, proceeds or dividends or distributions in respect thereof and after acquired-property) that secured the obligations to which such Liens relate; (10) Liens securing the Senior Secured Notes and the related guarantees; (11) Liens securing (x) Hedging Obligations and (y) obligations in respect of Cash Management Services; -20- (12) Liens on specific items of inventory or other goods and proceeds of any Person securing such Person’s obligations in respect of bankers’ acceptances or letters of credit issued or created for the account of such Person to facilitate the purchase, shipment or storage of such inventory or other goods; (13) leases, subleases, licenses or sublicenses (or other agreement under which the Issuer or any Restricted Subsidiary has granted rights to end users to access and use the Issuer’s or any Restricted Subsidiary’s products, technologies or services) granted to others in the ordinary course of business which do not materially interfere with the ordinary conduct of the business of the Issuer or any of its Restricted Subsidiaries and the customary rights reserved or vested in any Person by the terms of any lease, sublease, license, sublicense, grant or permit, or to require annual or periodic payments as a condition to the continuance thereof; (14) Liens arising from Uniform Commercial Code (or equivalent statutes) financing statement filings regarding operating leases, consignments or accounts entered into by the Issuer and its Restricted Subsidiaries in the ordinary course of business or consistent with industry practice or purported Liens evidenced by the filing of precautionary Uniform Commercial Code (or equivalent statutes) financing statements or similar public filings; (15) Liens in favor of the Issuer or any Subsidiary of the Issuer; (16) Liens on equipment of the Issuer or any of its Restricted Subsidiaries granted in the ordinary course of business or consistent with industry practice to the clients of the Issuer or any of its Restricted Subsidiaries; (17) Liens on accounts receivable, Securitization Assets and related assets incurred in connection with a Qualified Securitization Facility; (18) Liens to secure any modification, refinancing, refunding, extension, renewal or replacement (or successive modification, refinancing, refunding, extensions, renewals or replacements) as a whole, or in part, of any Indebtedness secured by any Lien referred to in the foregoing clauses (6), (7), (8) and (9); provided , that (a) such new Lien shall be limited to all or part of the same property (plus improvements, accessions, proceeds or dividends or distributions in respect thereof and after-acquired property) that secured the original Lien ( plus improvements and accessions on such property) and proceeds and products thereof, and (b) the Indebtedness secured by such Lien at such time is not increased to any amount greater than the sum of (i) the outstanding principal amount or, if greater, committed amount of the Indebtedness secured by a Lien under clauses (6), (7), (8) and (9) at the time the original Lien became a Permitted Lien under this Indenture, and (ii) an amount necessary to pay any fees and expenses (including original issue discount, upfront fees or similar fees) and premiums (including tender premiums and accrued and unpaid interest), related to such refinancing, refunding, extension, renewal or replacement; (19) deposits made or other security provided in the ordinary course of business to secure liability to insurance carriers or self-insurance arrangements; (20) Liens securing obligations in an aggregate principal amount at any one time outstanding not to exceed the greater of (a) $2,000,000,000 and (b) 50% of EBITDA for the most recently ended Test Period; -21- (21) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the importation of goods in the ordinary course of business; (22) (i) the prior rights of consignees and their lenders under consignment arrangements entered into in the ordinary course of business or consistent with industry practice, (ii) Liens arising out of conditional sale, title retention or similar arrangements for the sale of goods in the ordinary course of business or consistent with industry practice and (iii) Liens arising by operation of law under Article 2 of the Uniform Commercial Code; (23) Liens securing judgments for the payment of money not constituting an Event of Default under Section 6.01(5) hereof; (24) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the importation of goods in the ordinary course of business or consistent with industry practice; (25) Liens (a) of a collection bank arising under Section 4-208 of the Uniform Commercial Code on items in the course of collection, (b) attaching to commodity trading accounts or other commodity brokerage accounts incurred in the ordinary course of business, and (c) in favor of banking institutions arising as a matter of law or under general terms and conditions encumbering deposits (including the right of set-off) and which are within the general parameters customary in the banking industry; (26) Liens deemed to exist in connection with Investments in repurchase agreements; provided that such Liens do not extend to any assets other than those that are the subject of such repurchase agreement; (27) Liens encumbering reasonable customary deposits and margin deposits and similar Liens attaching to commodity trading accounts or other brokerage accounts incurred in the ordinary course of business and not for speculative purposes; (28) Liens that are contractual rights of set-off (a) relating to the establishment of depository relations with banks or other deposit-taking financial institutions and not given in connection with the issuance of Indebtedness, (b) relating to pooled deposit or sweep accounts of the Issuer or any of its Restricted Subsidiaries to permit satisfaction of overdraft or similar obligations incurred in the ordinary course of business of the Issuer and its Restricted Subsidiaries or consistent with industry practice or (c) relating to purchase orders and other agreements entered into with customers of the Issuer or any of its Restricted Subsidiaries in the ordinary course of business or consistent with industry practice; (29) Liens arising from Personal Property Security Act financing statement filings regarding leases entered into by the Issuer or any of its Restricted Subsidiaries in the ordinary course of business; (30) any encumbrance or restriction (including put, call arrangements, tag, drag, right of first refusal and similar rights) with respect to capital stock of any joint venture or similar arrangement pursuant to any joint venture or similar agreement; -22- (31) Liens arising out of conditional sale, title retention, consignment or similar arrangements for the sale or purchase of goods entered into by the Issuer or any Restricted Subsidiary in the ordinary course of business; (32) Liens solely on any cash earnest money deposits made by the Issuer or any of its Restricted Subsidiaries in connection with any letter of intent or purchase agreement; (33) ground leases in respect of real property on which facilities owned or leased by the Issuer or any of its Subsidiaries are located; (34) Liens on insurance policies and the proceeds thereof securing the financing of the premiums with respect thereto; (35) Liens on Capital Stock or other securities of an Unrestricted Subsidiary that secure Indebtedness or other obligations of such Unrestricted Subsidiary; (36) Liens on cash advances in favor of the seller of any property to be acquired in an Investment or other acquisition to be applied against the purchase price for such Investment or other acquisition; (37) any interest or title of a lessor, sublessor, licensor or sublicensor or secured by a lessor’s, sublessor’s, licensor’s or sublicensor’s interest under leases or licenses entered into by the Issuer or any of the Restricted Subsidiaries in the ordinary course of business or consistent with industry practice; (38) deposits of cash with the owner or lessor of premises leased and operated by the Issuer or any of its Subsidiaries in the ordinary course of business of the Issuer and such Subsidiary or consistent with industry practice to secure the performance of the Issuer’s or such Subsidiary’s obligations under the terms of the lease for such premises; (39) Liens arising in the ordinary course of business to secure accounts payable or similar trade obligations not constituting Indebtedness; (40) security given to a public utility or any municipality or governmental authority when required by such utility or authority in connection with the operations of that Person in the ordinary course of business; (41) any proxy agreement relating to IMS Government Solutions, Inc. and its Equity Interests entered into with the Defense Security Service; (42) any encumbrance or restriction imposed under any contract for the sale by the Issuer or any of its Restricted Subsidiaries of the Capital Stock of any Restricted Subsidiary, or any business unit or division of the Issuer or any Restricted Subsidiary; (43) Liens securing any Indebtedness incurred under any Secured Revolving Commitments established in compliance with the terms of this Indenture; (44) Liens securing the Notes and Guarantees, if any, of the Notes; and -23- (45) Liens securing obligations in respect of Indebtedness incurred under any Credit Facility, including any letter of credit facility relating thereto, that do not at any one time exceed $10,425,000,000. For purposes of this definition, the term “Indebtedness” shall be deemed to include interest and other obligations payable on and with respect to such Indebtedness. “ Person ” means any individual, corporation, limited liability company, partnership, joint venture, association, joint stock company, trust, unincorporated organization, government or any agency or political subdivision thereof or any other entity. “ Preferred Stock ” means any Equity Interest with preferential rights of payment of dividends or upon liquidation, dissolution, or winding up. “ Principal Personal or Real Property ” means any personal or real property (including, for the avoidance of doubt, accounts receivable and inventory) other than property that, in the opinion of the Issuer, is not of material importance to the total business conducted by the Issuer and its Subsidiaries, taken as a whole. “ Private Placement Legend ” means the legend set forth in Section 2.06(g)(i) hereof to be placed on all Notes issued under this Indenture, except where otherwise permitted by the provisions of this Indenture. “ Public Company Costs ” means the initial costs relating to establishing compliance with the Sarbanes-Oxley Act of 2002, as amended, and other expenses arising out of or incidental to the Issuer’s or its Restricted Subsidiaries’ initial establishment of compliance with the obligations of a reporting company, including costs, fees and expenses (including legal, accounting and other professional fees) relating to compliance with provisions of the Securities Act and the Exchange Act. “ QIB ” means a “qualified institutional buyer” as defined in Rule 144A. “ Qualified Equity Interests ” means any Equity Interests that are not Disqualified Stock. “ Qualified Securitization Facility ” means any Securitization Facility (1) constituting a securitization financing facility that meets the following conditions: (a) the Board of Directors shall have determined in good faith that such Securitization Facility (including financing terms, covenants, termination events and other provisions) is in the aggregate economically fair and reasonable to the Issuer and the applicable Restricted Subsidiary or Securitization Subsidiary and (b) all sales and/or contributions of Securitization Assets and related assets to the applicable Person or Securitization Subsidiary are made at fair market value (as determined in good faith by the Issuer) or (2) constituting a receivables financing facility (it being understood that, for the avoidance of doubt, the Receivables Facility is deemed to be a Qualified Securitization Facility). “ Rating Agencies ” means Moody’s and S&P or if Moody’s or S&P or both shall not make a rating on the Notes publicly available, a nationally recognized statistical rating agency or agencies, as the case may be, selected by the Issuer which shall be substituted for Moody’s or S&P or both, as the case may be. -24- “ Ratings Decline Period ” means, with respect to any Change of Control, the period that (1) begins on the earlier of (a) the date of the first public announcement of such Change of Control or of the Issuer’s intention to effect such Change of Control or (b) the occurrence of such Change of Control and (2) ends on the 60th calendar day following consummation of such Change of Control; provided , however , that such period shall be extended for so long as any Rating Agency rating the Notes as of the beginning of the Ratings Decline Period has publicly announced during the Ratings Decline Period that the rating of the Notes is under consideration for downgrade by such Rating Agency. “ Receivables Facility ” means the receivables facility pursuant to (a) that certain Receivables Financing Agreement, dated December 5, 2014, among IQVIA RDS Funding LLC, as borrower, IQVIA RDS Inc., as initial servicer, PNC Bank, N.A., as administrative agent and lender, and the additional persons from time to time party thereto as lenders and (b) that certain Purchase and Sale Agreement, dated December 5, 2014, as amended, among IQVIA RDS Inc., as originator and initial servicer, IQVIA CSMS US Inc., as originator, and IQVIA RDS Funding LLC, as buyer, in each case, as amended, modified or supplemented from time to time so long as such amendments, modifications and supplements are either, taken as a whole, not materially adverse to the interests of the Holders as determined in good faith by the Issuer or consented to by the administrative agent under the Senior Credit Facilities, and any extension thereof to receivables of the Issuer and any of its Subsidiaries. “ Record Date ” for the interest payable on any applicable Interest Payment Date means the close of business on the Clearing System Business Day immediately preceding such Interest Payment Date. “ Registered Equivalent Notes ” means, with respect to any notes originally issued in an offering pursuant to Rule 144A under the Securities Act or other private placement transaction under the Securities Act, substantially identical notes (having the same guarantees) issued in a dollar-for-dollar exchange therefor pursuant to an exchange offer registered with the SEC. “ Regulation S ” means Regulation S promulgated under the Securities Act. “ Regulation S Global Note ” means a Regulation S Temporary Global Note or Regulation S Permanent Global Note, as applicable. “ Regulation S Permanent Global Note ” means a permanent Global Note in the form of Exhibit A attached hereto, with such applicable legends as are provided herein, and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its nominee for the accounts of Euroclear and Clearstream issued in a denomination equal to the outstanding principal amount of the Regulation S Temporary Global Note upon expiration of the applicable Restricted Period. “ Regulation S Temporary Global Note ” means a temporary Global Note in the form of Exhibit A attached hereto, bearing the Global Note Legend, the Private Placement Legend and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its nominee for the accounts of Euroclear and Clearstream issued in a denomination equal to the outstanding principal amount of the Notes initially sold in reliance on Rule 903. “ Regulation S Temporary Global Note Legend ” means the legend set forth in Section 2.06(g)(iii) hereof. “ Responsible Officer ” means, when used with respect to the Trustee, any officer within the corporate trust department of the Trustee, including any director, vice president, assistant vice president, any trust officer or assistant trust officer or any other officer of the Trustee who customarily performs functions similar to those performed by the Persons who at the time shall be such officers, respectively, or to whom any corporate trust matter is referred because of such Person’s knowledge of and familiarity with the particular subject and, in each case, who shall have direct responsibility for the administration of this Indenture. -25- “ Restricted Period ” means, in respect of any Note issued pursuant to Regulation S, the 40-day distribution compliance period as defined in Regulation S applicable to such Note. “ Restricted Subsidiary ” means, at any time, any direct or indirect Subsidiary of the Issuer (including any Foreign Subsidiary) that is not then an Unrestricted Subsidiary; provided , that upon the occurrence of an Unrestricted Subsidiary ceasing to be an Unrestricted Subsidiary, such Subsidiary shall be included in the definition of “Restricted Subsidiary.” “ Rule 144 ” means Rule 144 promulgated under the Securities Act. “ Rule 144A ” means Rule 144A promulgated under the Securities Act. “ Rule 903 ” means Rule 903 promulgated under the Securities Act. “ Rule 904 ” means Rule 904 promulgated under the Securities Act. “ S&P ” means S&P Global Ratings, a division of S&P Global Inc., and any successor to its rating agency business. “ Sale and Lease-Back Transaction ” means any arrangement providing for the leasing for a period of more than three years by the Issuer or any of its Restricted Subsidiaries of any real or tangible personal property, which property has been or is to be sold or transferred by the Issuer or such Restricted Subsidiary to a third Person in contemplation of such leasing. “ SEC ” means the U.S. Securities and Exchange Commission. “ Secured Indebtedness ” means any Indebtedness of the Issuer or any of its Restricted Subsidiaries secured by a Lien. “ Secured Revolving Commitments ” means any commitments to make loans constituting Secured Indebtedness on a revolving basis to the Issuer or any of its Restricted Subsidiaries by any Person other than the Issuer or any of its Restricted Subsidiaries. “ Securities Act ” means the Securities Act of 1933, as amended, and the rules and regulations of the SEC promulgated thereunder. “ Securitization Assets ” means (a) the accounts receivable, royalty or other revenue streams and other rights to payment and other assets related thereto subject to a Qualified Securitization Facility and the proceeds thereof and (b) contract rights, lockbox accounts and records with respect to such accounts receivable and any other assets customarily transferred together with accounts receivable in a securitization financing. “ Securitization Facility ” means any of one or more receivables or securitization financing facilities, as amended, supplemented, modified, extended, renewed, restated or refunded from time to time, the Obligations of which are non-recourse (except for customary representations, warranties, covenants and indemnities made in connection with such facilities) to the Issuer or any of its Restricted Subsidiaries (other than a Securitization Subsidiary) pursuant to which the Issuer or any of its Restricted Subsidiaries sells or grants a security interest in its accounts receivable or Securitization Assets or assets related thereto to either (a) a Person that is not a Restricted Subsidiary or (b) a Securitization Subsidiary that in turn sells its accounts receivable to a Person that is not a Restricted Subsidiary. -26- “ Securitization Subsidiary ” means any Subsidiary formed for the purpose of, and that solely engages only in one or more Qualified Securitization Facilities and other activities reasonably related thereto. “ Senior Credit Facilities ” means, collectively, the senior secured term loan facilities and the senior secured revolving credit facilities under that certain Fifth Amended and Restated Credit Agreement, dated as of August 25, 2021, among the Issuer, Holdings, IQVIA RDS Inc., a North Carolina corporation, the Restricted Subsidiaries party thereto, Bank of America, N.A., as the administrative agent, and the lenders and other entities party thereto, including any guarantees, collateral documents, instruments and agreements executed in connection therewith, and any amendments, supplements, modifications, extensions, renewals, restatements, refundings, refinancings or replacements thereof and any one or more indentures or credit facilities or commercial paper facilities with banks or other institutional lenders, or investors, whether or not secured, that replace, refund, supplement or refinance any part of the loans, notes, other credit facilities or commitments thereunder, including any such replacement, refunding or refinancing facility or indenture that increases the amount borrowable thereunder or alters the maturity thereof or adds Restricted Subsidiaries as additional borrowers or guarantors thereunder and whether by the same or any other agent, trustee, lender or group of lenders or holders. “ Senior Indebtedness ” means: (1) all Indebtedness of the Issuer or any Guarantor outstanding under the Senior Credit Facilities, the Existing Senior Notes and the Notes and related Guarantees (including interest accruing on or after the filing of any petition in bankruptcy or similar proceeding or for reorganization of the Issuer or any Guarantor (at the rate provided for in the documentation with respect thereto, regardless of whether or not a claim for post-filing interest is allowed in such proceedings)), and any and all other fees, expense reimbursement obligations, indemnification amounts, penalties, and other amounts (whether existing on the Issue Date or thereafter created or incurred) and all obligations of the Issuer or any Guarantor to reimburse any bank or other Person in respect of amounts paid under letters of credit, acceptances or other similar instruments; (2) all (x) Hedging Obligations (and guarantees thereof) and (y) obligations in respect of Cash Management Services (and guarantees thereof) owing to a lender under the Senior Credit Facilities or any Affiliate of such lender (or any Person that was a lender or an Affiliate of such lender at the time the applicable agreement giving rise to such Hedging Obligation was entered into); provided that such Hedging Obligations and obligations in respect of Cash Management Services, as the case may be, are permitted to be incurred under the terms of this Indenture; (3) any other Indebtedness of the Issuer or any Guarantor permitted to be incurred under the terms of this Indenture, unless the instrument under which such Indebtedness is incurred expressly provides that it is subordinated in right of payment to the Notes or any related Guarantee; and (4) all Obligations with respect to the items listed in the preceding clauses (1), (2) and (3); -27- provided , that Senior Indebtedness shall not include: (a) any obligation of such Person to the Issuer or any of its Subsidiaries; (b) any liability for federal, state, local or other taxes owed or owing by such Person; (c) any accounts payable or other liability to trade creditors arising in the ordinary course of business or consistent with industry practice; (d) any Indebtedness or other Obligation of such Person which is subordinate or junior in any respect to any other Indebtedness or other Obligation of such Person; or (e) that portion of any Indebtedness which at the time of incurrence is incurred in violation of this Indenture. “ Senior 1.750% Notes ” means 550,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2026. “ Senior 1.750%/2.250% Notes Indenture ” means the indenture dated March 3, 2021, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time. “ Senior 2.250% Notes due 2028 ” means 720,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 2.250% Notes due 2028 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 2.250% Notes due 2028 Indenture ” means the indenture dated August 13, 2019, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time. “ Senior 2.250% Notes due 2029 ” means 900,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2029 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 1.750%/2.250% Notes Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 2.875% Notes due 2028 ” means 711,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 2.875% Notes due 2028 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 2.875% Notes due 2028 Indenture ” means the indenture dated June 24, 2020, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time. “ Senior 3.250% Notes ” means 1,425,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2025. -28- “ Senior 4.875% Notes ” means $800,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2023. “ Senior 5.000% Notes due 2026 ” means $1,050,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2026 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 5.000% Notes due 2026 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 5.000% Notes due 2026 Indenture ” means the indenture dated September 28, 2016, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time. “ Senior 5.000% Notes due 2027 ” means $1,100,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2027 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 5.000% Notes due 2027 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 5.000% Notes due 2027 Indenture ” means the indenture dated May 10, 2019, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time. “ Senior 6.250% Notes due 2032 ” means the $2,000,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2032 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 6.250% Notes due 2032 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 6.250% Notes due 2032 Indenture ” means the indenture dated June 4, 2025, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee, as amended, supplemented or modified from time to time. “ Senior 6.500% Notes due 2030 ” means the $500,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes due 2030 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 6.500% Notes due 2030 Indenture in exchange for the initial unregistered senior unsecured notes. “ Senior 6.500% Notes due 2030 Indenture ” means the indenture dated May 23, 2023, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee, as amended, supplemented or modified from time to time. “ Senior Secured 5.700% Notes due 2028 ” means the $750,000,000 in aggregate principal amount of the Issuer’s 5.700% senior secured notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior Secured 5.700% Notes due 2028 Indenture in exchange for the initial unregistered senior secured notes. “ Senior Secured 5.700% Notes due 2028 Indenture ” means the amended and restated indenture, dated December 19, 2023, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee and collateral agent, as amended, supplemented or modified from time to time. -29- “ Senior Secured 6.250% Notes due 2029 ” means the $1,250,000,000 in aggregate principal amount of the Issuer’s 6.250% senior secured notes due 2029 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior Secured 6.250% Notes due 2029 Indenture in exchange for the initial unregistered senior secured notes. “ Senior Secured 6.250% Notes due 2029 Indenture ” means the amended and restated indenture, dated December 19, 2023, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee and collateral agent, as amended, supplemented or modified from time to time. “ Senior Secured Net Leverage Ratio ” means, with respect to any Test Period, the ratio of (a) Consolidated Total Debt (other than any Indebtedness of a Restricted Subsidiary which is not a Guarantor which is not secured by any assets of the Issuer or a Guarantor) outstanding on the last day of such Test Period that is secured by a Lien on any property of the Issuer or any Restricted Subsidiary (other than property or assets held in a defeasance or similar trust or arrangement for the benefit of the Indebtedness secured thereby) minus the aggregate amount of cash and cash equivalents included in the consolidated balance sheet of the Issuer as of such date, excluding cash and cash equivalents which are listed as “Restricted” on such balance sheet, to (b) EBITDA of the Issuer for such Test Period. In the event that the Issuer or any Restricted Subsidiary incurs, assumes, guarantees, redeems, repays, retires or extinguishes any Secured Indebtedness (other than Secured Indebtedness incurred under any revolving credit facility in the ordinary course of business for working capital purposes or any repayment of such Indebtedness in the ordinary course of business) subsequent to the commencement of the period for which the Senior Secured Net Leverage Ratio is being calculated but prior to or simultaneously with the event for which such calculation is made, then the Senior Secured Net Leverage Ratio, as applicable, shall be calculated giving pro forma effect to such incurrence, assumption, guarantee, redemption, repayment, retirement or extinguishment of Secured Indebtedness, in each case, as if the same had occurred on the last day of the applicable Test Period, and if the Senior Secured Net Leverage Ratio is being calculated in connection with establishing any Secured Revolving Commitments, then such calculation shall be made giving pro forma effect to the incurrence of the entire committed amount of Secured Indebtedness under such Secured Revolving Commitments. For purposes of making the computation referred to above, any Specified Transaction that has been made by the Issuer or any of its Restricted Subsidiaries during any Test Period or subsequent to such Test Period and on or prior to or simultaneously with the event for which the calculation of the Senior Secured Net Leverage Ratio is made shall be calculated on a pro forma basis assuming that all such Specified Transactions (and the change in EBITDA resulting therefrom) had occurred on the first day of the Test Period. If since the beginning of such Test Period any Person that subsequently became a Restricted Subsidiary or was merged, amalgamated or consolidated with or into the Issuer or any of its Restricted Subsidiaries since the beginning of such Test Period shall have made any Specified Transaction that would have required adjustment pursuant to this definition, then EBITDA shall be calculated giving pro forma effect thereto for such Test Period as if such Specified Transaction had occurred at the beginning of the applicable Test Period. For purposes of this definition, whenever pro forma effect is to be given to any Specified Transaction, the pro forma calculations shall be made in good faith by a Financial Officer of the Issuer and may include, for the avoidance of doubt, the amount of “run-rate” cost savings, synergies and operating expense reductions resulting from or related to any such Specified Transaction which is being given pro forma effect that have been realized or are expected to be realized and for which the actions necessary to realize such cost savings, operating expense reductions and synergies are taken, committed to be taken or with respect to which substantial steps have been taken or are expected to be taken no later than 24 months after the date of any such Specified Transaction (in each case as though such cost savings -30- and synergies had been realized on the first day of the applicable period and as if such cost savings and synergies were realized for the entirety of such period). For the purposes of this Indenture, “ run-rate ” means the full recurring benefit for a period that is associated with any action taken, committed to be taken, or with respect to which substantial steps have been taken or are expected to be taken (including any savings expected to result from the elimination of a public target’s compliance costs with public company requirements), net of the amount of actual benefits realized during such period from such actions. For purposes of this definition, the amount of any Secured Indebtedness in a currency other than U.S. dollars will be converted to U.S. dollars based on the average exchange rate for such currency for the most recent twelve month period immediately prior to the date of determination in a manner consistent with that used in calculating EBITDA for the applicable period (after giving effect to the currency translation effects, determined in accordance with GAAP, of hedging arrangements for currency exchange risks with respect to the applicable currency in effect on the date of determination of the applicable amount of such Indebtedness). “ Senior Secured Notes ” means, collectively, the Senior Secured 5.700% Notes due 2028 and Senior Secured 6.250% Notes due 2029. “ Significant Subsidiary ” means any Restricted Subsidiary that would be a “significant subsidiary” as defined in Article 1, Rule 1-02 of Regulation S-X of the SEC, as such regulation is in effect on the Issue Date; provided that notwithstanding the foregoing, in no event will any Securitization Subsidiary be considered a Significant Subsidiary for purposes of clauses (4), (5), (6), (7) or (8) under Section 6.01. “ Specified Legal Expenses ” means, to the extent not constituting an extraordinary, non-recurring or unusual loss, charge or expense, all attorneys’ and experts’ fees and expenses and all other costs, liabilities (including all damages, penalties, fines and indemnification and settlement payments) and expenses paid or payable in connection with any threatened, pending, completed or future claim, demand, action, suit, proceeding, inquiry or investigation (whether civil, criminal, administrative, governmental or investigative) either (i) arising from, or related to, facts and circumstances existing on or prior to the Issue Date or (ii) arising out of or related to antitrust, Federal Trade Commission or Department of Justice proceedings or securities law. “ Specified Transaction ” means (i) solely for the purposes of determining the applicable cash balance, any contribution of capital, including as a result of an Equity Offering, to the Issuer, in each case, in connection with an acquisition or Investment, (ii) any designation of operations or assets of the Issuer or a Restricted Subsidiary as discontinued operations (as defined under GAAP) (other than held-for-sale discontinued operations until actually disposed of), (iii) any Investment that results in a Person becoming a Restricted Subsidiary, (iv) any designation of a Subsidiary as a Restricted Subsidiary or an Unrestricted Subsidiary in compliance with this Indenture, (v) any purchase or other acquisition of a business of any Person, of assets constituting a business unit, line of business or division of any Person, or (vi) any disposition (x) that results in a Restricted Subsidiary ceasing to be a Subsidiary of the Issuer or (y) of a business, business unit, line of business or division of the Issuer or a Restricted Subsidiary, in each case whether by merger, amalgamation, consolidation or otherwise. “ Subordinated Indebtedness ” means, with respect to the Notes, (1) any Indebtedness of the Issuer which is by its terms subordinated in right of payment to the Notes, and -31- (2) any Indebtedness of any Guarantor which is by its terms subordinated in right of payment to the Guarantee of such entity of the Notes. “ Subsidiary ” means, with respect to any Person: (1) any corporation, association, or other business entity (other than a partnership, joint venture, limited liability company or similar entity) of which more than 50.0% of the total voting power of shares of Capital Stock entitled (without regard to the occurrence of any contingency) to vote in the election of directors, members of management or trustees thereof is at the time of determination owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof; and (2) any partnership, joint venture, limited liability company or similar entity of which: (a) more than 50.0% of the capital accounts, distribution rights, total equity and voting interests or general or limited partnership interests, as applicable, are owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof whether in the form of membership, general, special or limited partnership or otherwise, and (b) such Person or any Restricted Subsidiary of such Person is a controlling general partner or otherwise controls such entity. “ Test Period ” means the Issuer’s most recently ended four fiscal quarters for which internal financial statements are available (as determined in good faith by the Issuer). “ TISE ” means The International Stock Exchange. “ TISEAL ” means The International Stock Exchange Authority Limited. “ Trustee ” means U.S. Bank Trust Company, National Association, in its capacity as trustee, until a successor replaces it in accordance with the applicable provisions of this Indenture and thereafter means the successor serving hereunder. “ Uniform Commercial Code ” means the Uniform Commercial Code or any successor provision thereof as the same may from time to time be in effect in the State of New York. “ Unrestricted Subsidiary ” means (a) any Subsidiary of the Issuer which at the time of determination is designated as an “Unrestricted Subsidiary” in any Credit Facility (including the Senior Credit Facilities), whether on or subsequent to the Issue Date, and (b) any Subsidiary of an Unrestricted Subsidiary. “ U.S. Person ” means a U.S. person as defined in Rule 902(k) under the Securities Act. “ Voting Stock ” of any Person as of any date means the Capital Stock of such Person that is at the time entitled to vote in the election of the Board of Directors of such Person. “ Wholly-Owned Subsidiary ” of any Person means a Subsidiary of such Person, 100.0% of the outstanding Equity Interests of which (other than directors’ qualifying shares and shares of Capital Stock of Foreign Subsidiaries issued to foreign nationals as required under applicable law) shall at the time be owned by such Person and/or by one or more Wholly-Owned Subsidiaries of such Person. -32- SECTION 1.02. Other Definitions. Term Defined in Section “Applicable Premium Deficit” 8.04 “Authentication Order” 2.02 “Change of Control Offer” 4.07(a) “Change of Control Payment” 4.07(a) “Change of Control Payment Date” 4.07(a)(2) “Covenant Defeasance” 8.03 “Equity Offering Redemption Amount” 3.07 “Event of Default” 6.01 “Initial Notes” Recitals “LCT Election” 1.05 “Legal Defeasance” 8.02 “Note Register” 2.03 “Notes” Recitals “Paying Agent” 2.03 “Redemption Date” 3.01 “Registrar” 2.03 “Transfer Agent” 2.03 SECTION 1.03. Rules of Construction . Unless the context otherwise requires: (a) a term has the meaning assigned to it; (b) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP; (c) “or” is not exclusive; -33- (d) the words “including,” “includes” and similar words shall be deemed to be followed by without limitation; (e) words in the singular include the plural, and in the plural include the singular; (f) “will” shall be interpreted to express a command; (g) provisions apply to successive events and transactions; (h) references to sections of, or rules under, the Securities Act or the Exchange Act shall be deemed to include substitute, replacement or successor sections or rules adopted by the SEC from time to time; (i) unless the context otherwise requires, any reference to an “Article,” “Section” or “clause” refers to an Article, Section or clause, as the case may be, of this Indenture; (j) the words “herein,” “hereof” and “hereunder” and other words of similar import refer to this Indenture as a whole and not any particular Article, Section, clause or other subdivision; (k) the principal amount of any Preferred Stock at any time shall be (i) the maximum liquidation value of such Preferred Stock at such time or (ii) the maximum mandatory redemption or mandatory repurchase price with respect to such Preferred Stock at such time, whichever is greater; (l) words used herein implying any gender shall apply to both genders; (m) in the computation of periods of time from a specified date to a later specified date, the word “from” means “from and including”; the words “to” and “until” each mean “to but excluding”; and the word “through” means “to and including”; (n) the principal amount of any non-interest bearing Indebtedness or other discount security constituting Indebtedness at any date shall be the principal amount thereof that would be shown on a balance sheet of the Issuer dated such date prepared in accordance with GAAP; and (o) unless otherwise specifically indicated, the term “consolidated” with respect to any Person means such Person consolidated with its Restricted Subsidiaries and excludes any Unrestricted Subsidiary as if such Unrestricte…

Document text

EX-4.1 · d157492dex41.htm

EX-4.1
 2
 d157492dex41.htm
 EX-4.1

 Exhibit 4.1

 INDENTURE
 Dated as of
June 11, 2026
 among

 IQVIA Inc., as Issuer,
 the
Guarantors party hereto
 and

 U.S. Bank Trust Company, National Association,

 as Trustee
 4.625% SENIOR NOTES
DUE 2033

 TABLE OF CONTENTS

 Page

 ARTICLE I

 DEFINITIONS AND INCORPORATION BY REFERENCE

 SECTION 1.01.

 Definitions

 1

 SECTION 1.02.

 Other Definitions

 33

 SECTION 1.03.

 Rules of Construction

 33

 SECTION 1.04.

 Acts of Holders

 34

 SECTION 1.05.

 Limited Condition Transactions

 35

 ARTICLE II

 THE NOTES

 SECTION 2.01.

 Form and Dating; Terms

 36

 SECTION 2.02.

 Execution and Authentication

 37

 SECTION 2.03.

 Registrar, Transfer Agent and Paying Agent

 38

 SECTION 2.04.

 Paying Agent Provisions

 38

 SECTION 2.05.

 Holder Lists

 39

 SECTION 2.06.

 Transfer and Exchange

 39

 SECTION 2.07.

 Replacement Notes

 47

 SECTION 2.08.

 Outstanding Notes

 48

 SECTION 2.09.

 Treasury Notes

 48

 SECTION 2.10.

 Temporary Notes

 48

 SECTION 2.11.

 Cancellation

 48

 SECTION 2.12.

 Defaulted Interest

 49

 SECTION 2.13.

 ISIN and/or Common Code Numbers

 49

 ARTICLE III

 REDEMPTION

 SECTION 3.01.

 Notices to Trustee

 49

 SECTION 3.02.

 Selection of Notes to Be Redeemed

 50

 SECTION 3.03.

 Notice of Redemption

 50

 SECTION 3.04.

 Effect of Notice of Redemption

 51

 SECTION 3.05.

 Deposit of Redemption Price

 51

 SECTION 3.06.

 Notes Redeemed in Part

 52

 SECTION 3.07.

 Optional Redemption.

 52

 SECTION 3.08.

 Mandatory Redemption

 53

 ARTICLE IV

 COVENANTS

 SECTION 4.01.

 Payment of Notes

 53

 SECTION 4.02.

 Maintenance of Office or Agency

 54

 -i-

 Page

 SECTION 4.03.

 Reports and Other Information

 54

 SECTION 4.04.

 Compliance Certificate

 56

 SECTION 4.05.

 Stay, Extension and Usury Laws

 57

 SECTION 4.06.

 Company Existence

 57

 SECTION 4.07.

 Offer to Repurchase Upon Change of Control Triggering Event

 57

 SECTION 4.08.

 Limitation on Liens

 59

 SECTION 4.09.

 Limitation on Sale and Lease-Back Transactions

 60

 SECTION 4.10.

 Exempted Transactions

 60

 SECTION 4.11.

 Additional Subsidiary Guarantees

 61

 ARTICLE V

 SUCCESSORS

 SECTION 5.01.

 Merger, Consolidation or Sale of All or Substantially All Assets

 61

 SECTION 5.02.

 Successor Person Substituted

 62

 ARTICLE VI

 DEFAULTS AND REMEDIES

 SECTION 6.01.

 Events of Default

 62

 SECTION 6.02.

 Acceleration

 64

 SECTION 6.03.

 Other Remedies

 64

 SECTION 6.04.

 Waiver of Past Defaults

 65

 SECTION 6.05.

 Control by Majority

 65

 SECTION 6.06.

 Limitation on Suits

 65

 SECTION 6.07.

 Collection Suit by Trustee

 65

 SECTION 6.08.

 Restoration of Rights and Remedies

 65

 SECTION 6.09.

 Rights and Remedies Cumulative

 66

 SECTION 6.10.

 Delay or Omission Not Waiver

 66

 SECTION 6.11.

 Trustee May File Proofs of Claim

 66

 SECTION 6.12.

 Priorities

 66

 SECTION 6.13.

 Undertaking for Costs

 67

 ARTICLE VII

 TRUSTEE

 SECTION 7.01.

 Duties of Trustee

 67

 SECTION 7.02.

 Rights of Trustee

 68

 SECTION 7.03.

 Individual Rights of Trustee

 69

 SECTION 7.04.

 Trustee’s Disclaimer

 70

 SECTION 7.05.

 Notice of Defaults

 70

 SECTION 7.06.

 [Reserved]

 70

 SECTION 7.07.

 Compensation and Indemnity

 70

 SECTION 7.08.

 Replacement of Trustee

 71

 SECTION 7.09.

 Successor Trustee by Merger, etc.

 72

 SECTION 7.10.

 Eligibility; Disqualification

 72

 -ii-

 Page

 ARTICLE VIII

 LEGAL DEFEASANCE AND COVENANT DEFEASANCE

 SECTION 8.01.

 Option to Effect Legal Defeasance or Covenant Defeasance

 72

 SECTION 8.02.

 Legal Defeasance and Discharge

 72

 SECTION 8.03.

 Covenant Defeasance

 73

 SECTION 8.04.

 Conditions to Legal or Covenant Defeasance

 73

 SECTION 8.05.

 Deposited Money and Euro Government Obligations; Other Miscellaneous Provisions

 75

 SECTION 8.06.

 Repayment to Issuer

 75

 SECTION 8.07.

 Reinstatement

 75

 ARTICLE IX

 AMENDMENT, SUPPLEMENT AND WAIVER

 SECTION 9.01.

 Without Consent of Holders

 75

 SECTION 9.02.

 With Consent of Holders

 77

 SECTION 9.03.

 [Reserved]

 78

 SECTION 9.04.

 Revocation and Effect of Consents

 78

 SECTION 9.05.

 Notation on or Exchange of Notes

 78

 SECTION 9.06.

 Trustee to Sign Amendments, etc.

 78

 ARTICLE X

 GUARANTEES

 SECTION 10.01.

 Guarantee

 79

 SECTION 10.02.

 Limitation on Guarantor Liability

 80

 SECTION 10.03.

 Execution and Delivery

 81

 SECTION 10.04.

 Subrogation

 81

 SECTION 10.05.

 Benefits Acknowledged

 81

 SECTION 10.06.

 Release of Guarantees

 81

 ARTICLE XI

 SATISFACTION AND DISCHARGE

 SECTION 11.01.

 Satisfaction and Discharge

 82

 SECTION 11.02.

 Application of Trust Money

 83

 ARTICLE XII

 MISCELLANEOUS

 SECTION 12.01.

 [Reserved]

 84

 SECTION 12.02.

 Notices

 84

 SECTION 12.03.

 [Reserved]

 85

 SECTION 12.04.

 Certificate and Opinion as to Conditions Precedent

 85

 SECTION 12.05.

 Statements Required in Certificate or Opinion

 85

 -iii-

 Page

 SECTION 12.06.

 Rules by Trustee and Agents

 86

 SECTION 12.07.

 No Personal Liability of Directors, Officers, Employees and Stockholders

 86

 SECTION 12.08.

 Governing Law

 86

 SECTION 12.09.

 Waiver of Jury Trial

 86

 SECTION 12.10.

 Force Majeure

 86

 SECTION 12.11.

 No Adverse Interpretation of Other Agreements

 86

 SECTION 12.12.

 Successors

 86

 SECTION 12.13.

 Severability

 87

 SECTION 12.14.

 Counterpart Originals

 87

 SECTION 12.15.

 Table of Contents, Headings, etc.

 87

 SECTION 12.16.

 [Reserved]

 87

 SECTION 12.17.

 USA PATRIOT Act

 87

 EXHIBITS

 Exhibit A

 Form of Note

 Exhibit B

 Form of Certificate of Transfer

 Exhibit C

 Form of Certificate of Exchange

 Exhibit D

 Form of Supplemental Indenture to Be Delivered by Subsequent Guarantors

 -iv-

 INDENTURE, dated as of June 11, 2026, among IQVIA Inc., a Delaware corporation, each
Guarantor (as defined herein) and U.S. Bank Trust Company, National Association, as trustee (the “Trustee”).
 W I
 T N E S S E T H
 WHEREAS, the Issuer (as defined herein) has duly authorized the issuance
of 950,000,000 aggregate principal amount of 4.625% Senior Notes due 2033 issued on the date hereof (the “ Initial Notes ”); and

 WHEREAS, the Issuer and each of the Guarantors have duly authorized the execution and delivery of this Indenture (as defined herein).

 NOW, THEREFORE, each party hereto agrees as follows for the benefit of each other and for the equal and ratable benefit of the Holders (as
defined herein).
 ARTICLE I

 DEFINITIONS AND INCORPORATION BY REFERENCE

 SECTION 1.01. Definitions.

 “ 144A Global Note ” means a Global Note substantially in the form of Exhibit A attached hereto, with such applicable
legends as are provided herein, and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its nominee for the
accounts of Euroclear and Clearstream, issued in a denomination equal to the outstanding principal amount of the Notes sold in reliance on Rule 144A.

 “ Additional Notes ” means additional Notes (other than the Initial Notes) issued under this Indenture in accordance with
Section 2.02 hereof, as part of the same series as the Initial Notes.
 “ Affiliate ” of any specified Person means
any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified Person. For purposes of this definition, “ control ” (including, with correlative meanings, the
terms “ controlling ,” “ controlled by ” and “ under common control with ”), as used with respect to any Person, shall mean the possession, directly or indirectly, of the power to direct or cause
the direction of the management or policies of such Person, whether through the ownership of voting securities, by agreement or otherwise.

 “ Agent ” means any Registrar, co-registrar, Transfer Agent, co-transfer agent, principal Paying Agent or additional paying agent.
 “ Applicable
Premium ” means, with respect to any Note on any Redemption Date, the greater of:
 (1) 1.0% of the principal
amount of such Note; and
 (2) the excess, if any, of (a) the present value at such Redemption Date of (i) the
redemption price of such Note at June 15, 2029 (such redemption price being set forth in the table appearing in Section 3.07(d) hereof), plus (ii) all required remaining scheduled interest payments due on such Note through
June 15, 2029, excluding accrued but unpaid interest to the Redemption Date, computed using a discount rate equal to the Bund Rate as of such Redemption

Date plus 50 basis points; over (b) the then outstanding principal amount of such Note on such Redemption Date, as calculated by the Issuer or on behalf of the Issuer by such Person as the
Issuer shall designate; provided , that such calculation shall not be the duty or obligation of the Trustee.
 “ Applicable
Procedures ” means, with respect to any transfer or exchange of or for beneficial interests in any Global Note, the rules and procedures of Euroclear and Clearstream, as applicable, that apply to such transfer or exchange.

 “ Attributable Indebtedness ” means, with respect to any Sale and Lease-Back Transaction, at the time of determination, the
lesser of (1) the sale price of the property so leased multiplied by a fraction the numerator of which is the remaining portion of the base term of the lease included in such transaction and the denominator of which is the base term of such
lease, and (2) the total obligation (discounted to the present value at the implicit interest factor, determined in accordance with GAAP, included in the rental payments) of the lessee for rental payments (other than amounts required to be paid
on account of property taxes as well as maintenance, repairs, insurance, water rates and other items which do not constitute payments for property rights) during the remaining portion of the base term of the lease included in such transaction.
Notwithstanding the foregoing, if such Sale and Lease-Back Transaction results in a Capitalized Lease Obligation, the amount of Indebtedness represented thereby will be determined in accordance with the definition of “Capitalized Lease
Obligation.”
 “ August 2019 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer
or any Restricted Subsidiary in connection with the August 2019 Transactions.
 “ August 2019 Transactions ” means,
collectively, (i) the issuance of the Senior 2.250% Notes due 2028, (ii) the satisfaction and discharge of the Senior 4.875% Notes and (iii) the payment of all fees and expenses associated with the foregoing.

 “ Bankruptcy Law ” means Title 11, U.S. Code, as amended, or any similar federal or state law for the relief of debtors.

 “ Board of Directors ” means, for any Person, the board of directors or other governing body of such Person or, if such
Person does not have such a board of directors or other governing body and is owned or managed by a single entity, the Board of Directors of such entity, or, in either case, any committee thereof duly authorized to act on behalf of such Board of
Directors. Unless otherwise provided, “Board of Directors” means the Board of Directors of the Issuer.
 “ Book-Entry
Interest ” means a beneficial interest in a Global Note held by or through a Participant.
 “ Bund Rate ” means
with respect to any redemption date, the greater of (x) 0% and (y) the rate per annum equal to the equivalent yield to maturity as of such redemption date of the Comparable German Bund Issue, assuming a price for the Comparable German Bund
Issue (expressed as a percentage of its principal amount) equal to the Comparable German Bund Price for such redemption date, where:
 (a)
“ Comparable German Bund Issue ” means the German Bundesanleihe security selected by any Reference German Bund Dealer as having a fixed maturity most nearly equal to the period from such redemption date to June 15, 2029, and
that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of euro denominated corporate debt securities in a principal amount approximately equal to the then outstanding principal
amount of the Notes and of a maturity most nearly equal to June 15, 2029; provided however , that, if the period from

 -2-

such redemption date to June 15, 2029 is not equal to the fixed maturity of the German Bundesanleihe security selected by such Reference German Bund Dealer, the Bund Rate shall be determined
by linear interpolation (calculated to the nearest one-twelfth of a year) from the yields of German Bundesanleihe securities having a fixed maturity (i) most nearly before June 15, 2029 and
(ii) most nearly after June 15, 2029, in each case, for which such yields are given; provided , further , that if the period from such redemption date to June 15, 2029 is less than one year, a fixed maturity of one year
shall be used;
 (b) “ Comparable German Bund Price ” means, with respect to any redemption date, the average of the
Reference German Bund Dealer Quotations for such redemption date, after excluding the highest and lowest such Reference German Bund Dealer Quotations, or if the Issuer obtains fewer than four such Reference German Bund Dealer Quotations, the average
of all such quotations;
 (c) “ Reference German Bund Dealer ” means any dealer of German Bundesanleihe securities
appointed by the Issuer (and notified to the Trustee); and
 (d) “ Reference German Bund Dealer Quotations ” means, with
respect to each Reference German Bund Dealer and any redemption date, the average of the bid and offered prices for the Comparable German Bund Issue (expressed in each case as a percentage of its principal amount) (as determined by the Issuer)
quoted in writing to the Issuer by such Reference German Bund Dealer at 3:30 p.m. Frankfurt, Germany time on the third Business Day preceding such redemption date.

 “ Business Day ” means each day which is not a Legal Holiday.

 “ Capital Stock ” means:

 (1) in the case of a corporation, corporate stock or shares in the capital of such corporation;

 (2) in the case of an association or business entity, any and all shares, interests, participations, rights or other
equivalents (however designated) of corporate stock;
 (3) in the case of a partnership or limited liability company,
partnership or membership interests (whether general or limited); and
 (4) any other interest or participation that confers
on a Person the right to receive a share of the profits and losses of, or distributions of assets of, the issuing Person but excluding from all of the foregoing any debt securities convertible into Capital Stock, whether or not such debt securities
include any right of participation with Capital Stock.
 “ Capitalized Lease Obligation ” means, at the time any
determination thereof is to be made, the amount of the liability in respect of a capital lease that would at such time be required to be capitalized and reflected as a liability on a balance sheet (excluding the footnotes thereto) prepared in
accordance with GAAP; provided that all obligations of any Person that would be characterized as operating lease obligations in accordance with GAAP without giving effect to Accounting Standards Codification Topic No. 842, Leases
(whether or not such operating lease obligations were in effect on the Issue Date) shall be accounted for as operating lease obligations (and not as Capitalized Lease Obligations or Indebtedness) for purposes of this Indenture regardless of the
effectiveness of Accounting Standards Codification Topic No. 842, Leases , or any other change in GAAP following the Issue Date that would otherwise require such obligations to be recharacterized (on a prospective or retroactive basis or
otherwise) as Capitalized Lease Obligations.

 -3-

 “ Capitalized Software Expenditures ” means, for any period, the aggregate
of all expenditures (whether paid in cash or accrued as liabilities) by a Person and its Restricted Subsidiaries during such period in respect of licensed or purchased software or internally developed software and software enhancements that, in
conformity with GAAP, are or are required to be reflected as capitalized costs on the consolidated balance sheet of a Person and its Restricted Subsidiaries.

 “ Cash Management Services ” means any agreement or arrangement to provide cash management services, including treasury,
depository, overdraft, credit card processing or credit or debit card, purchase card, electronic funds transfer (including automated clearing house fund transfer services) and other cash management arrangements.

 “ Change of Control ” means the occurrence of any of the following after the Issue Date:

 (1) the sale, lease, transfer, conveyance or other disposition in one or a series of related transactions (other than by
merger, consolidation or amalgamation) of all or substantially all of the assets of the Issuer and its Subsidiaries, taken as a whole, to any Person; or

 (2) the Issuer becomes aware of (by way of a report or any other filing pursuant to Section 13(d) of the Exchange Act,
proxy, vote, written notice or otherwise) the acquisition by (A) any Person or (B) Persons that are together a group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act, or any successor provision),
including any such group acting for the purpose of acquiring, holding or disposing of securities (within the meaning of Rule 13d-5(b)(1) under the Exchange Act), in a single transaction or in a related series
of transactions, by way of merger, amalgamation, consolidation or other business combination or purchase of beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act, or any successor
provision) of 50.0% or more of the total voting power of the Voting Stock of the Issuer directly or indirectly through any of its direct or indirect parent holding companies, other than in each case, in connection with any transaction or series of
transactions in which the Issuer shall become the Wholly-Owned Subsidiary of a Parent Company.
 “ Change of Control Triggering
Event ” means the occurrence of: (1) if on the earlier of (a) the date of the first public announcement of a Change of Control or of the Issuer’s intention to effect such Change of Control and (b) the occurrence of such
Change of Control, the Notes have an Investment Grade Rating from both Rating Agencies, (i) a Change of Control that is accompanied or followed by a downgrade of the Notes within the Ratings Decline Period for such Change of Control by both
Rating Agencies and (ii) each Rating Agency’s rating of the Notes on any day during such Ratings Decline Period for such Change of Control is below the rating by such Rating Agency in effect immediately preceding the first public
announcement of the Change of Control (or the occurrence thereof if such Change of Control occurs prior to the first public announcement thereof); provided , however , that a downgrade of the Notes by the applicable Rating Agency will
not be deemed to have occurred in respect of a Change of Control (and thus will not be deemed a downgrade for purposes of this definition) if such Rating Agency making the reduction in rating does not publicly announce or confirm or inform the
Issuer or the Trustee in writing at the request of the Issuer that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the Change of Control (whether or not the
applicable Change of Control has occurred at the time of such downgrade) or (2) if the Notes do not have an Investment Grade Rating from both Rating Agencies, a Change of Control. No Change of Control Triggering Event will be deemed to
have occurred in connection with a Change of Control until such Change of Control has been consummated.
 “ Clearing System
Business Day ” means a weekday (Monday to Friday, inclusive) except December 25 and January 1.

 -4-

 “ Clearstream ” means Clearstream Banking, Soci&eacute;t&eacute; Anonyme,
Luxembourg and its successors.
 “ Common Depositary ” means, with respect to the Notes issuable or issued in whole or in
part in global form, a depositary common to Euroclear and Clearstream, which have initially appointed U.S. Bank Europe DAC, and any and all successors thereto appointed as Common Depositary hereunder and having become such pursuant to the applicable
provision of this Indenture.
 “ Consolidated Depreciation and Amortization Expense ” means with respect to any Person for
any period, the total amount of depreciation and amortization expense of such Person and its Restricted Subsidiaries, including, the amortization of intangible assets, deferred financing fees, debt issuance costs, commissions, fees and expenses and
amortization of Capitalized Software Expenditures of such Person and its Restricted Subsidiaries for such period on a consolidated basis and otherwise determined in accordance with GAAP.

 “ Consolidated Interest Expense ” means, with respect to any Person for any period, without duplication, the sum of:

 (1) consolidated interest expense of such Person and its Restricted Subsidiaries for such period, to the extent such expense
was deducted (and not added back) in computing Consolidated Net Income (including (a) amortization of original issue discount resulting from the issuance of Indebtedness at less than par, (b) all commissions, discounts and other fees and
charges owed with respect to letters of credit or bankers acceptances, (c) non-cash interest payments (but excluding any non-cash interest expense attributable to
the movement in the mark to market valuation of Hedging Obligations or other derivative instruments pursuant to GAAP), (d) the interest component of Capitalized Lease Obligations, and (e) net payments, if any, made (less net payments, if any,
received), pursuant to interest rate Hedging Obligations with respect to Indebtedness, and excluding (q) any prepayment premium or penalty, (r) annual agency fees paid to the administrative agents and collateral agents under any Credit
Facilities, (s) costs associated with obtaining Hedging Obligations and breakage costs in respect of Hedging Obligations related to interest rates, (t) any expense resulting from the discounting of any indebtedness in connection with the
application of recapitalization accounting or, if applicable, purchase accounting in connection with any acquisition (or purchase of assets), (u) penalties and interest related to taxes, (v) any “additional interest” or
“liquidated damages” with respect to other securities, (w) amortization or expensing of deferred financing fees, amendment and consent fees, debt issuance costs, commissions, fees and expenses, (x) any amortization or expensing
of bridge, commitment and other financing fees and any other fees related to the May 2019 Transactions, the August 2019 Transactions, the June 2020 Transactions, the March 2021 Transactions, the May 2023 Transactions, the November 2023 Transactions,
the June 2025 Transactions, the June 2026 Transactions or any acquisitions (or purchases of assets) after the Issue Date, (y) commissions, discounts, yield and other fees and charges (including any interest expense) related to any Qualified
Securitization Facility and (z) any accretion of accrued interest on discounted liabilities (other than Indebtedness except to the extent arising from the application of purchase accounting)); plus

 (2) consolidated capitalized interest of such Person and its Restricted Subsidiaries for such period, whether paid or accrued;
 less
 (3) interest income of such Person and its Restricted Subsidiaries for such period.

 -5-

 For purposes of this definition, interest on a Capitalized Lease Obligation shall be deemed
to accrue at an interest rate reasonably determined by such Person to be the rate of interest implicit in such Capitalized Lease Obligation in accordance with GAAP.

 “ Consolidated Net Income ” means, with respect to any Person for any period, the aggregate of the Net Income of such Person
and its Restricted Subsidiaries for such period, on a consolidated basis, and otherwise determined in accordance with GAAP; provided , however , that, without duplication,

 (1) any net after-tax effect of extraordinary,
 non-recurring or unusual gains or losses, charges or expenses (including relating to any multi-year strategic initiatives), the May 2019 Transaction Expenses, the August 2019 Transaction Expenses, the June
2020 Transaction Expenses, the March 2021 Transaction Expenses, the May 2023 Transaction Expenses, the November 2023 Transaction Expenses, the June 2025 Transaction Expenses, the June 2026 Transaction Expenses, restructuring costs and reserves,
duplicative running costs, relocation costs, expenses related to any reconstruction, decommissioning, recommissioning or reconfiguration of fixed assets for alternative uses, Public Company Costs, facility consolidation and closing costs, severance
costs and expenses, one-time compensation charges, costs relating to pre-opening and opening costs for facilities, signing, retention or completion bonuses, executive
recruiting costs, costs incurred in connection with any strategic initiatives, transition costs, costs incurred in connection with non-ordinary course product and intellectual property development, costs
incurred in connection with acquisitions (or purchases of assets) prior to or after the Issue Date (including integration costs), other business optimization expenses (including costs and expenses relating to business optimization programs, and new
systems design, retention charges, system establishment costs and implementation costs and project start-up costs), accruals and reserves, operating expenses attributable to the implementation of cost-savings
initiatives, consulting fees and curtailments and modifications to pension and post-retirement employee benefit plans shall be excluded;

 (2) the cumulative effect of a change in accounting principles and changes as a result of the adoption or modification of
accounting policies during such period whether effected through a cumulative effect adjustment or a retroactive application, in each case in accordance with GAAP, shall be excluded;

 (3) any net after-tax effect of gains or losses on disposal, abandonment (including
asset retirement costs) or discontinuance of disposed, abandoned or discontinued operations, as applicable, shall be excluded;

 (4) any net after-tax effect of gains or losses (less all fees, expenses and charges
relating thereto) attributable to asset dispositions or abandonments or the sale or other disposition of any Equity Interests of any Person other than in the ordinary course of business, as determined in good faith by the Issuer, shall be excluded;

 (5) the Net Income for such period of any Person that is an Unrestricted Subsidiary shall be excluded; provided
that Consolidated Net Income of a Person shall be increased by the amount of dividends or distributions or other payments that are actually paid in cash (or to the extent converted into cash) to such Person or a Restricted Subsidiary thereof in
respect of such period;
 (6) [reserved];

 -6-

 (7) effects of adjustments (including the effects of such adjustments pushed
down to such Person and its Restricted Subsidiaries) in such Person’s consolidated financial statements pursuant to GAAP (including in the inventory, property and equipment, software, goodwill, intangible assets, in process research and
development, deferred revenue and debt line items) attributable to the application of recapitalization accounting or purchase accounting, as the case may be, in relation to any consummated acquisition or joint venture investment or the amortization
or write-off or write-down of any amounts thereof, net of taxes, shall be excluded;

 (8) any net after-tax effect of income (loss) from the early extinguishment or
conversion of (a) Indebtedness, (b) Hedging Obligations or (c) other derivative instruments shall be excluded;

 (9) any impairment charge or asset write-off or write-down in each case, pursuant to
GAAP, and the amortization of intangibles arising pursuant to GAAP shall be excluded;
 (10) any equity-based or non-cash compensation charge or expense, including any such charge or expense arising from grants of stock appreciation, equity incentive programs or similar rights, stock options, restricted stock or other rights,
shall be excluded;
 (11) any fees, expenses or charges incurred during such period, or any amortization thereof for such
period, in connection with any acquisition, Investment, disposition, incurrence or repayment of Indebtedness (including such fees, expenses or charges related to the offering and issuance of the Notes, the Existing Senior Notes and the syndication
and incurrence of any Credit Facilities), issuance of Equity Interests, recapitalization, refinancing transaction or amendment or modification of any debt instrument (including any amendment or other modification of the Notes, the Existing Senior
Notes and other securities and any Credit Facilities) and including, in each case, any such transaction whether consummated on, after or prior to the Issue Date and any such transaction undertaken but not completed, and any charges or non-recurring merger costs incurred during such period as a result of any such transaction, in each case whether or not successful or consummated (including, for the avoidance of doubt, the effects of expensing all
transaction related expenses in accordance with Accounting Standards Codification Topic No. 805, Business Combinations ), shall be excluded;

 (12) accruals and reserves that are established or adjusted within twelve months after the closing of any acquisition that are
so required to be established as a result of such acquisition in accordance with GAAP shall be excluded;
 (13) any
expenses, charges or losses to the extent covered by insurance or indemnity and actually reimbursed, or, so long as such Person has made a determination that there exists reasonable evidence that such amount will in fact be reimbursed by the insurer
or indemnifying party and only to the extent that such amount is in fact reimbursed within 365 days of the date of the insurable or indemnifiable event (net of any amount so added back in any prior period to the extent not so reimbursed within the
applicable 365-day period), shall be excluded;
 (14) any noncash compensation
expense resulting from the application of Accounting Standards Codification Topic No. 718, Compensation — Stock Compensation or Accounting Standards Codification Topic 505-50,
Equity-Based Payments to Non-Employees , shall be excluded; and

 -7-

 (15) the following items shall be excluded:

 (a) research and development expenses and charges to the extent expensed; and

 (b) earn-out and contingent consideration obligations (including to the extent
accounted for as bonuses or otherwise) and adjustments thereof and purchase price adjustments.
 In addition, to the extent not already
included in the Consolidated Net Income of such Person and its Restricted Subsidiaries, notwithstanding anything to the contrary in the foregoing, Consolidated Net Income shall include the amount of proceeds received from business interruption
insurance and reimbursements of any expenses and charges that are covered by indemnification or other reimbursement provisions in connection with any acquisition, Investment or any sale, conveyance, transfer or other disposition of assets.

 “ Consolidated Total Debt ” means, as of any date of determination, the aggregate principal amount of Indebtedness of the
Issuer and its Restricted Subsidiaries outstanding on such date, determined on a consolidated basis in accordance with GAAP (but excluding the effects of any discounting of Indebtedness resulting from the application of purchase accounting in
connection with any acquisition), consisting only of Indebtedness for borrowed money, Capitalized Lease Obligations, debt obligations evidenced by bonds, notes, debentures, promissory notes or similar instruments and guarantees of Indebtedness of
such types of a third Person; provided that Consolidated Total Debt shall not include Indebtedness in respect of (i) any Qualified Securitization Facility, (ii) any letter of credit, except to the extent of obligations in respect of
drawn standby letters of credit which have not been reimbursed within three (3) Business Days and (iii) Hedging Obligations, except any unpaid termination payments thereunder. The U.S. dollar-equivalent principal amount of any Indebtedness
denominated in a foreign currency will reflect the currency translation effects, determined in accordance with GAAP, of Hedging Obligations for currency exchange risks with respect to the applicable currency in effect on the date of determination of
the U.S. dollar-equivalent principal amount of such Indebtedness.
 “ Contingent Obligations ” means, with respect to any
Person, any obligation of such Person guaranteeing any leases, dividends or other obligations that do not constitute Indebtedness (“ primary obligations ”) of any other Person (the “ primary obligor ”) in any
manner, whether directly or indirectly, including any obligation of such Person, whether or not contingent:
 (1) to
purchase any such primary obligation or any property constituting direct or indirect security therefor;
 (2) to advance or
supply funds
 (a) for the purchase or payment of any such primary obligation, or

 (b) to maintain working capital or equity capital of the primary obligor or otherwise to maintain the net worth or solvency of
the primary obligor; or
 (3) to purchase property, securities or services primarily for the purpose of assuring the owner
of any such primary obligation of the ability of the primary obligor to make payment of such primary obligation against loss in respect thereof.

 -8-

 “ Controlled Investment Affiliate ” means, as to any Person, any other
Person which directly or indirectly is in control of, is controlled by, or is under common control with such Person and is organized by such Person (or any Person controlling such Person) primarily for making direct or indirect equity or debt
investments in the Issuer and/or other companies.
 “ Corporate Trust Office of the Trustee ” shall be at the address of
the Trustee specified in Section 12.02 hereof or such other address as to which the Trustee may give notice to the Holders and the Issuer.

 “ Credit Facilities ” means, with respect to the Issuer or any of its Restricted Subsidiaries, one or more debt facilities,
including the Senior Credit Facilities or other financing arrangements (including commercial paper facilities or indentures) providing for revolving credit loans, term loans, letters of credit or other long-term indebtedness, including any notes,
mortgages, guarantees, collateral documents, instruments and agreements executed in connection therewith, and any amendments, supplements, modifications, extensions, renewals, restatements or refundings thereof, in whole or in part, and any
indentures or credit facilities or commercial paper facilities that replace, refund, supplement or refinance any part of the loans, notes, other credit facilities or commitments thereunder, including any such replacement, refunding, supplemental or
refinancing facility, arrangement or indenture that increases the amount permitted to be borrowed or issued thereunder or alters the maturity thereof or adds Restricted Subsidiaries as additional borrowers or guarantors thereunder and whether by the
same or any other agent, trustee, lender or group of lenders or holders.
 “ Default ” means any event that is, or with
the passage of time or the giving of notice or both would be, an Event of Default.
 “ Definitive Note ” means a
certificated Note registered in the name of the Holder thereof and issued in accordance with Section 2.06(c) hereof, substantially in the form of Exhibit A attached hereto, except that such Note shall not bear the Global Note Legend and
shall not have the “Schedule of Exchanges of Interests in the Global Note” attached thereto.
 “ Disqualified
Stock ” means, with respect to any Person, any Capital Stock of such Person which, by its terms, or by the terms of any security into which it is convertible or for which it is redeemable or exchangeable, or upon the happening of any event,
matures or is mandatorily redeemable (other than for any Qualified Equity Interests or solely as a result of a change of control, asset sale, casualty, condemnation or eminent domain) pursuant to a sinking fund obligation or otherwise, or is
redeemable at the option of the holder thereof (other than for any Qualified Equity Interests or solely as a result of a change of control, asset sale, casualty, condemnation or eminent domain), in whole or in part, in each case prior to the date 91
days after the earlier of the maturity date of the Notes or the date the Notes are no longer outstanding; provided , that if such Capital Stock is issued to any plan for the benefit of future, current or former employees, directors, officers,
members of management, consultants or independent contractors (or their respective Controlled Investment Affiliates or Immediate Family Members or any permitted transferee thereof) of the Issuer or its Subsidiaries or any direct or indirect parent
company of the Issuer or by any such plan to such employees, directors, officers, members of management, consultants or independent contractors (or their respective Controlled Investment Affiliates or Immediate Family Members or any permitted
transferee thereof), such Capital Stock shall not constitute Disqualified Stock solely because it may be redeemable or subject to repurchase by the Issuer or its Subsidiaries pursuant to any such plan or agreement or in order to satisfy applicable
statutory or regulatory obligations or as a result of such employee’s, director’s, officer’s, management member’s, consultant’s or independent contractor’s termination, death or disability; provided ,
 further , that any Capital Stock held by any future, current or former employee, director, officer, member of management, consultant or independent contractor (or their respective Controlled Investment Affiliates or Immediate

 -9-

Family Members or any permitted transferee thereof) of the Issuer, any of its Subsidiaries, any of its direct or indirect parent companies or any other entity in which the Issuer or a Restricted
Subsidiary has an Investment and is designated in good faith as an “affiliate” by the Board of Directors (or the compensation committee thereof), in each case pursuant to any stock subscription or shareholders’ agreement,
management equity plan or stock option plan or any other management or employee benefit plan or agreement shall not constitute Disqualified Stock solely because it may be required to be repurchased by the Issuer or its Subsidiaries or in order to
satisfy applicable statutory or regulatory obligations or as a result of such employee’s, director’s, officer’s, management member’s, consultant’s or independent contractor’s termination, death or disability.

 “ EBITDA ” means, with respect to any Person for any period, the Consolidated Net Income of such Person and its Restricted
Subsidiaries for such period:
 (1) increased (without duplication) by the following, in each case (other than in the case
of clauses (g) and (j)) to the extent deducted (and not added back) in determining Consolidated Net Income for such period:

 (a) provision for taxes based on income or profits or capital, including federal, state, franchise, property, excise and
similar taxes and foreign withholding taxes (including any future taxes or other levies which replace or are intended to be in lieu of such taxes and any penalties and interest related to such taxes or arising from tax examinations) and the net tax
expense associated with any adjustments made pursuant to clauses (1) through (15) of the definition of “Consolidated Net Income”; plus

 (b) Fixed Charges for such period (including (x) net losses under Hedging Obligations or other derivative instruments
entered into for the purpose of hedging interest rate risk, (y) bank fees and other deferred financing fees, and (z) costs of surety bonds in connection with financing activities, plus amounts excluded from Consolidated Interest Expense as
set forth in clauses (1)(q) through (z) in the definition thereof); plus
 (c) Consolidated Depreciation and
Amortization Expense for such period; plus
 (d) any other non-cash charges,
including any write-offs or write-downs reducing Consolidated Net Income for such period ( provided that if any such non-cash charges represent an accrual or reserve for potential cash items in any
future period, (A) the Issuer may determine not to add back such non-cash charge in the current period and (B) to the extent the Issuer does decide to add back such
 non-cash charge, the cash payment in respect thereof in such future period shall be subtracted from EBITDA to such extent, and excluding amortization of a prepaid cash item that was paid in a prior period);
 plus
 (e) the amount of any reductions in arriving at Net Income resulting from the application of Accounting
Standards Codification Topic No. 810, Consolidation ; plus
 (f) the amount of management, monitoring,
consulting, transaction, advisory and other fees (including termination fees) and indemnities and expenses paid or accrued in such period to the Persons with an equity interest in the Issuer or its direct or indirect parent companies; plus

 -10-

 (g) the amount of “run rate” net cost savings, synergies and
operating expense reductions (other than any of the foregoing related to Specified Transactions) projected by the Issuer in good faith to result from actions taken, committed to be taken or with respect to which substantial steps have been taken or
are expected in good faith to be taken no later than twenty-four (24) months after the end of such period (calculated on a pro forma basis as though such cost savings, operating expense reductions and synergies had been
realized on the first day of the period for which EBITDA is being determined and if such cost savings, operating expense reductions and synergies were realized during the entirety of such period), net of the amount of actual benefits realized during
such period from such actions; provided , that such cost savings, operating expense reductions and synergies are reasonably identifiable and factually supportable (it is understood and agreed that
 “run-rate” means the full recurring benefit for a period that is associated with any action taken, committed to be taken or with respect to which substantial steps have been taken or are expected
to be taken); plus
 (h) the amount of loss on sale of receivables, Securitization Assets and related assets to any
Securitization Subsidiary in connection with a Qualified Securitization Facility; plus
 (i) any costs or expense
incurred pursuant to any management equity plan, stock option plan or any other management or employee benefit plan, agreement or any stock subscription or shareholder agreement, to the extent that such costs or expenses are funded with cash
proceeds contributed to the capital of such Person or net cash proceeds of an issuance of Equity Interests of such Person (other than Disqualified Stock); plus

 (j) cash receipts (or any netting arrangements resulting in reduced cash expenditures) not representing EBITDA or Consolidated
Net Income in any period to the extent non-cash gains relating to such income were deducted in the calculation of EBITDA pursuant to clause (2) below for any previous period and not added back;
 plus
 (k) any net loss from disposed, abandoned or discontinued operations (excluding
 held-for-sale discontinued operations until actually disposed of); plus

 (l) Specified Legal Expenses; and

 (2) decreased (without duplication) by the following, in each case to the extent included in determining Consolidated Net
Income for such period:
 (a) non-cash gains increasing Consolidated Net Income for
such period, excluding any non-cash gains that represent the reversal of an accrual or reserve for any anticipated cash charges in any prior period (other than any such accrual or reserve that has been added
back to Consolidated Net Income in calculating EBITDA in accordance with this definition); plus
 (b) any non-cash gains with respect to cash actually received in a prior period unless such cash did not increase EBITDA in such prior period; plus

 (c) any net income from disposed, abandoned or discontinued operations (excluding held-for-sale discontinued operations until actually disposed of); and

 -11-

 (3) increased (by losses) or decreased (by gains), as applicable, by the
following, without duplication, in each case, except for the adjustments set forth in the proviso to this clause (3), to the extent included in computing Consolidated Net Income for such period:

 (a) any net gain or loss resulting in such period from Hedging Obligations and the application of Accounting Standards
Codification Topic No. 815, Derivatives and Hedging ;
 (b) any net gain or loss resulting in such period from a
sale of Securitization Assets to a Securitization Subsidiary in connection with a Qualified Securitization Facility;
 (c)
any realized or unrealized gains or losses in such period from (i) balance sheet currency translation, (ii) currency translation of assets or liabilities that are not denominated in the functional currency of a Person into the functional
currency of that Person and (iii) Hedging Obligations that are designated by a Person as a hedge of an asset or liability in clause (c)(i) or (ii); and

 (d) any adjustments resulting from the application of Accounting Standards Codification Topic No. 460, Guarantees ,
or any comparable regulation;
 provided that, notwithstanding the foregoing, EBITDA shall include (without duplication) (i) any net realized
gain or loss from any Hedging Obligations accounted for as cash flow hedges of intercompany royalties and (ii) any net realized gain or loss from any Hedging Obligations that are designated by the Issuer as EBITDA hedges, except to the extent
any such Hedging Obligations are terminated by such Person prior to their scheduled maturity.
 “ Equity Interests ” means
Capital Stock and all warrants, options or other rights to acquire Capital Stock, but excluding any debt security that is convertible into, or exchangeable for, Capital Stock.

 “ Equity Offering ” means any public or private sale of common stock or Preferred Stock of the Issuer or any of its direct or
indirect parent companies (excluding Disqualified Stock), other than:
 (1) public offerings with respect to the
Issuer’s or any direct or indirect parent company’s common stock registered on Form S-4 or Form S-8; or

 (2) issuances to any Subsidiary of the Issuer.

 “ Euro Government Obligations ” means any security that is (1) a direct obligation of any country that is a member of
the European Monetary Union whose long-term debt is rated ‘‘A-1’’ or higher by Moody’s or ‘‘A+’’ or higher by S&P or the equivalent rating category of
another internationally recognized rating agency on the date of this Indenture, for the payment of which the full faith and credit of such country is pledged or (2) an obligation of a person controlled or supervised by and acting as an agency
or instrumentality of any such country the payment of which is unconditionally guaranteed as a full faith and credit obligation by such country, which, in either case under the preceding clauses (1) and (2), is not callable or redeemable at the
option of the issuer thereof and shall also include a depository receipt issued by a bank (as defined in Section 3(a)(2) of the Securities Act), as custodian with respect to any such Euro Government Obligations or a specific payment of
principal of or interest on any such Euro Government Obligations held by such custodian for the account of the holder of such depository receipt; provided that (except as required by law) such custodian is not authorized to make any deduction
from the amount payable to the holder of such depository receipt from any amount received by the custodian in respect of the Euro Government Obligations or the specific payment of principal of or interest on the Euro Government Obligations evidenced
by such depository receipt.

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 “ Euroclear ” means Euroclear Bank SA/NV, as operator of the Euroclear
system, and its successors.
 “ Euros ” or “  ” means the currency introduced at the start of the
third stage of the European economic and monetary union pursuant to the Treaty establishing the European Community, as amended by the Treaty on European Union.

 “ Exchange Act ” means the Securities Exchange Act of 1934, as amended, and the rules and regulations of the SEC promulgated
thereunder.
 “ Existing Senior Notes ” means, collectively, the Senior 2.250% Notes due 2028, the Senior 2.250% Notes due
2029, the Senior 2.875% Notes due 2028, the Senior 5.000% Notes due 2026, the Senior 5.000% Notes due 2027, the Senior Secured 5.700% Notes due 2028, the Senior Secured 6.250% Notes due 2029, the Senior 6.500% Notes due 2030 and the Senior 6.250%
Notes due 2032.
 “ fair market value ” means, with respect to any asset or liability, the fair market value of such asset
or liability as determined by the Issuer in good faith.
 “ Financial Officer ” means the Chief Financial Officer, the
Treasurer or other financial officer of the Issuer, as applicable.
 “ Fixed Charges ” means, with respect to any Person
for any period, the sum of, without duplication:
 (1) Consolidated Interest Expense of such Person for such period;

 (2) all cash dividends or other distributions paid (excluding items eliminated in consolidation) on any series of Preferred
Stock during such period; and
 (3) all cash dividends or other distributions paid (excluding items eliminated in
consolidation) on any series of Disqualified Stock during such period.
 “ Foreign Subsidiary ” means, with respect to any
Person, (a) any Restricted Subsidiary of such Person that is not organized or existing under the laws of the United States, any state thereof or the District of Columbia and any Restricted Subsidiary of such Foreign Subsidiary and (b) any
Restricted Subsidiary that is treated as a disregarded entity for United States federal income tax purposes and substantially all of whose assets consist of Equity Interests and/or Indebtedness of one or more Foreign Subsidiaries and any Restricted
Subsidiary of such Foreign Subsidiary.
 “ Funded Debt ” means any Indebtedness for money borrowed (other than in
connection with a Qualified Securitization Facility), whether created, issued, incurred, assumed or guaranteed, that would, in accordance with GAAP, be classified as long-term debt, but in any event including all Indebtedness for money borrowed,
whether secured or unsecured, maturing more than one year, or extendible at the option of the obligor to a date more than one year, after the date of determination thereof (excluding any amount thereof included in current liabilities other than
Indebtedness incurred under a revolving credit facility).

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 “ GAAP ” means (1) generally accepted accounting principles in the
United States of America which are in effect on the Issue Date but without giving effect to Accounting Standards Codification Topic No. 842, Leases or (2) after the Issue Date, if elected by the Issuer by written notice to the
Trustee in connection with the delivery of financial statements and information, the accounting standards and interpretations (“ IFRS ”) adopted by the International Accounting Standard Board, as in effect on the first date of the
period for which the Issuer is making such election; provided , that (a) any such election once made shall be irrevocable, (b) all financial statements and reports required to be provided after such election pursuant to this
Indenture shall be prepared on the basis of IFRS, (c) from and after such election, all ratios, computations and other determinations based on GAAP contained in this Indenture shall be computed in conformity with IFRS and (d) in connection
with the delivery of financial statements (x) for any of its first three financial quarters of any financial year, it shall restate its consolidated interim financial statements for such interim financial period and the comparable period in the
prior year to the extent previously prepared in accordance with GAAP as in effect on the Issue Date and (y) for delivery of audited annual financial information, it shall provide consolidated historical financial statements prepared in
accordance with IFRS for the prior most recent fiscal year to the extent previously prepared in accordance with GAAP as in effect on the Issue Date.

 “ Global Note Legend ” means the legend set forth in Section 2.06(g)(ii) hereof, which is required to be placed on all
Global Notes issued under this Indenture.
 “ Global Notes ” means, individually and collectively, a 144A Global Note and
a Regulation S Global Note.
 “ guarantee ” means a guarantee (other than by endorsement of negotiable instruments for
collection in the ordinary course of business or consistent with industry practice), direct or indirect, in any manner (including letters of credit and reimbursement agreements in respect thereof), of all or any part of any Indebtedness or other
obligations.
 “ Guarantee ” means the guarantee by any Guarantor of the Issuer’s Obligations under this Indenture
and the Notes.
 “ Guarantor ” means each Restricted Subsidiary of the Issuer, if any, that Guarantees the Notes in
accordance with the terms of this Indenture.
 “ Hedging Obligations ” means, with respect to any Person, the obligations
of such Person under any interest rate swap agreement, interest rate cap agreement, interest rate collar agreement, commodity swap agreement, commodity cap agreement, commodity collar agreement, foreign exchange contract, currency swap agreement or
similar agreement providing for the transfer, modification or mitigation of interest rate, currency or commodity risks either generally or under specific contingencies.

 “ Holder ” means the Person in whose name a Note is registered on the Registrar’s books.

 “ Holdings ” means IQVIA Holdings Inc., a Delaware corporation.

 “ Immediate Family Members ” means with respect to any individual, such individual’s child, stepchild, grandchild or
more remote descendant, parent, stepparent, grandparent, spouse, former spouse, qualified domestic partner, sibling, mother-in-law, father-in-law, son-in-law and daughter-in-law
(including adoptive relationships) and any trust, partnership or other bona fide estate-planning vehicle the only beneficiaries of which are any of the foregoing individuals or any private foundation or fund that is controlled by any of the
foregoing individuals or any donor-advised fund of which any such individual is the donor.

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 “ Indebtedness ” means, with respect to any Person, without duplication:

 (1) any indebtedness (including principal and premium) of such Person, whether or not contingent:

 (a) in respect of borrowed money;

 (b) evidenced by bonds, notes, debentures or similar instruments or letters of credit or bankers’ acceptances (or,
without duplication, reimbursement agreements in respect thereof);
 (c) representing the balance deferred and unpaid of the
purchase price of any property (including Capitalized Lease Obligations) due more than twelve months after such property is acquired, except (i) any such balance that constitutes an obligation in respect of a commercial letter of credit, a
trade payable or similar obligation to a trade creditor, in each case accrued in the ordinary course of business or consistent with industry practice, (ii) any earn-out obligations until such obligation
becomes a liability on the balance sheet of such Person in accordance with GAAP and is not paid within thirty (30) days after becoming due and payable or (iii) accruals for payroll and other liabilities accrued in the ordinary course of
business; or
 (d) representing the net obligations under any Hedging Obligations;

 if and to the extent that any of the foregoing Indebtedness (other than obligations in respect of letters of credit and Hedging Obligations)
would appear as a liability upon a balance sheet (excluding the footnotes thereto) of such Person prepared in accordance with GAAP; provided , that Indebtedness of any direct or indirect parent of the Issuer appearing upon the balance sheet of
the Issuer solely by reason of push-down accounting under GAAP shall be excluded;
 (2) to the extent not otherwise
included, any obligation by such Person to be liable for, or to pay, as obligor, guarantor or otherwise, on the obligations of the type referred to in clause (1) of a third Person (whether or not such items would appear upon the balance sheet
of such obligor or guarantor), other than by endorsement of negotiable instruments for collection in the ordinary course of business or consistent with industry practice; and

 (3) to the extent not otherwise included, the obligations of the type referred to in clause (1) of a third Person secured
by a Lien on any asset owned by such first Person, whether or not such Indebtedness is assumed by such first Person; provided that the amount of such Indebtedness that is not recourse to the Issuer or any Restricted Subsidiary except with
respect to such specific asset will be the lesser of (i) the fair market value of such asset at such date of determination, and (ii) the amount of such Indebtedness of such other Person;

 provided , that notwithstanding the foregoing, Indebtedness shall be deemed not to include (a) Contingent Obligations incurred in the ordinary
course of business or consistent with industry practice, (b) reimbursement obligations under commercial letters of credit ( provided that unreimbursed amounts under letters of credit shall be counted as Indebtedness three
(3) Business Days after such amount is drawn), (c) obligations under or in respect of Qualified Securitization Facilities; provided , further , that Indebtedness shall be calculated without giving effect to the effects of Accounting
Standards Codification Topic No. 815, Derivatives and Hedging , and related interpretations to the extent such effects would otherwise increase or decrease an amount of Indebtedness for any purpose under this Indenture as a result of
accounting for any embedded derivatives created by the terms of such Indebtedness or (d) deferred or prepaid revenues. For the avoidance of doubt, Indebtedness shall not include royalty payments.

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 “ Indenture ” means this Indenture, as amended, supplemented or otherwise
modified from time to time.
 “ Indirect Participant ” means a Person who holds a beneficial interest in a Global Note
through a Participant.
 “ Initial Purchasers ” means J.P. Morgan Securities plc, Barclays Bank PLC, Merrill Lynch
International, Citigroup Global Markets Limited, Goldman Sachs & Co. LLC, HSBC Securities (USA) Inc., MUFG Securities EMEA plc, PNC Capital Markets LLC, TD Securities (USA) LLC, Truist Securities, Inc., Wells Fargo Securities International
Limited, BNP Paribas, Fifth Third Securities, Inc., ING Financial Markets LLC, RBC Europe Limited, Regions Securities LLC and Huntington Securities, Inc.

 “ Interest Payment Date ” means June 15 and December 15 of each year to stated maturity, beginning
December 15, 2026.
 “ Investment Grade Rating ” means a rating equal to or higher than Baa3 (or the equivalent) by
Moody’s and BBB- (or the equivalent) by S&P, or an equivalent rating by any other Rating Agency selected by the Issuer.

 “ Investments ” means, with respect to any Person, all investments by such Person in other Persons (including Affiliates) in
the form of loans (including guarantees), advances or capital contributions (excluding accounts receivable, credit card and debit card receivables, trade credit, advances to customers, commission, travel and similar advances to employees, directors,
officers, members of management, manufacturers, consultants and independent contractors, in each case made in the ordinary course of business or consistent with industry practice), and purchases or other acquisitions for consideration of
Indebtedness, Equity Interests or other securities issued by any other Person.
 “ Issue Date ” means June 11, 2026.

 “ Issuer ” means IQVIA Inc. and its successors.

 “ Issuer’s Order ” means a written request or order signed on behalf of the Issuer by an Officer, who must be the
principal executive officer, the principal financial officer, the treasurer or the principal accounting officer of the Issuer, and delivered to the Trustee.

 “ June 2020 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the June 2020 Transactions.
 “ June 2020 Transactions ” means, collectively, (i) the
issuance of the Senior 2.875% Notes due 2028, (ii) the satisfaction and discharge of the Senior 3.500% Notes and (iii) the payment of all fees and expenses associated with the foregoing.

 “ June 2025 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the June 2025 Transactions.

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 “ June 2025 Transactions ” means, collectively, (i) the issuance of
Senior 6.250% Notes due 2032, (ii) the prepayment of $1,700.0 million of revolving loans under the Senior Credit Facilities and (iii) the payment of all fees and expenses associated with the foregoing.

 “ June 2026 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the June 2026 Transactions.
 “ June 2026 Transactions ” means, collectively, (i) the
issuance of the Notes on the Issue Date and (ii) the payment of all fees and expenses associated with the foregoing.
 “ LCT
Test Date ” means the date specified in the LCT Election; provided , that (a) with respect to any prepayment of Indebtedness, such date shall be the date of the irrevocable prepayment notice and (b) with respect to all other
Limited Condition Transactions, such date shall be the date of the definitive agreements for such Limited Condition Transaction.

 “ Legal Holiday ” means a Saturday, a Sunday or a day on which commercial banking institutions are not required to be open in
the State of New York, London or at the place of payment. If a payment date is on a Legal Holiday, payment will be made on the next succeeding day that is not a Legal Holiday and no interest shall accrue in, or be payable in respect of, the
intervening period.
 “ Lien ” means, with respect to any asset, any mortgage, lien (statutory or otherwise), pledge,
hypothecation, charge, security interest or encumbrance of any kind in respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law, including any conditional sale or other title retention agreement, any lease in
the nature thereof, any option or other agreement to sell or give a security interest in and any filing of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction; provided ,
that in no event shall an operating lease be deemed to constitute a Lien.
 “ Limited Condition Transaction ” means any
(a) acquisition, Investment or Sale and Lease-Back Transaction by the Issuer or one or more of its Restricted Subsidiaries whose consummation is not conditioned on the availability of, or on obtaining, third-party financing and
(b) redemption, repurchase, defeasance, satisfaction and discharge or repayment of Indebtedness requiring irrevocable notice in advance of such redemption, repurchase, defeasance, satisfaction and discharge or repayment.

 “ March 2021 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the March 2021 Transactions.
 “ March 2021 Transactions ” means, collectively, (i) the
issuance of the Senior 1.750% Notes and the Senior 2.250% Notes due 2029, (ii) the satisfaction and discharge of the Senior 3.250% Notes and (iii) the payment of all fees and expenses associated with the foregoing.

 “ May 2019 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the May 2019 Transactions.
 “ May 2019 Transactions ” means, collectively, (i) the
issuance of the 5.000% Senior Notes due 2027 and (ii) the payment of all fees and expenses associated with the foregoing.

 “ May 2023 Transaction Expenses ” means any fees, costs or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the May 2023 Transactions.

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 “ May 2023 Transactions ” means, collectively, (i) the issuance of the
Senior 6.500% Notes due 2030, (ii) the issuance of the Senior Secured 5.700% Notes due 2028 and (iii) the payment of all fees and expenses associated with the foregoing.

 “ Moody’s ” means Moody’s Investors Service, Inc. and any successor to its rating agency business.

 “ Net Income ” means, with respect to any Person, the net income (loss) of such Person, determined in accordance with GAAP
and before any reduction in respect of Preferred Stock dividends.
 “ Net Proceeds ” means the aggregate cash proceeds
received by the Issuer or any of its Restricted Subsidiaries in respect of any Sale and Lease-Back Transaction, net of the costs relating to such Sale and Lease-Back Transaction, including legal, accounting and investment banking fees, payments made
in order to obtain a necessary consent or required by applicable law, and brokerage and sales commissions, any relocation expenses incurred as a result thereof, other fees and expenses, including title and recordation expenses, taxes paid or payable
as a result thereof or any transactions occurring or deemed to occur to effectuate a payment under this Indenture (after taking into account any available tax credits or deductions and any tax sharing arrangements), amounts required to be applied to
the repayment of principal, premium, if any, and interest on Indebtedness (other than Subordinated Indebtedness) or amounts required to be applied to the repayments of Indebtedness secured by a Lien on such assets and required to be paid as a result
of such transaction and any deduction of appropriate amounts to be provided by the Issuer or any of its Restricted Subsidiaries as a reserve in accordance with GAAP against any liabilities associated with the Sale and Lease-Back Transaction and
retained by the Issuer or any of its Restricted Subsidiaries after such Sale and Lease-Back Transaction, including any indemnification obligations associated with such transaction.

 “ Non-U.S. Person ” means a Person who is not a U.S. Person.

 “ Notes ” means, collectively, the Initial Notes and any Additional Notes.

 “ Notes Custodian ” means the custodian with respect to the Global Notes (as appointed by the Common Depositary) or any
successor person thereto, and shall initially be U.S. Bank Europe DAC.
 “ November 2023 Transaction Expenses ” means any
fees, costs or expenses incurred and paid by the Issuer or any Restricted Subsidiary in connection with November 2023 Transactions.

 “ November 2023 Transactions ” means, collectively, (i) the issuance of Senior Secured 6.250% Notes due 2029 and
(ii) the payment of all fees and expenses associated with the foregoing.
 “ Obligations ” means any principal,
interest, fees and expenses (including any such interest, fees and expenses accruing on or subsequent to the filing of a petition in bankruptcy, reorganization or similar proceeding, whether or not such interest, fees or expenses is an allowed or
allowable claim under applicable state, federal or foreign law), premium, penalties, indemnifications, reimbursements (including reimbursement obligations with respect to letters of credit and banker’s acceptances), damages and other
liabilities, and guarantees of payment of such principal, interest, penalties, fees, indemnifications, reimbursements, damages and other liabilities, payable under the documentation governing any Indebtedness.

 “ Offering Memorandum ” means the confidential offering memorandum, dated June 4, 2026, relating to the sale of the
Initial Notes.

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 “ Officer ” means the Chairman of the Board of Directors, the Chief
Executive Officer, the Chief Financial Officer, the Chief Operating Officer, the President, any Executive Vice President, Senior Vice President or Vice President, the Treasurer or the Secretary of any Person. Unless otherwise indicated, Officer
shall refer to an Officer of the Issuer.
 “ Officer’s Certificate ” means a certificate signed on behalf of a
Person by an Officer of such Person that meets the requirements set forth in this Indenture.
 “ Opinion of Counsel ”
means a written opinion from legal counsel who is acceptable to the Trustee. The counsel may be an employee of or counsel to the Issuer or the Trustee.

 “ Parent Company ” means any Person so long as such Person directly or indirectly holds 100.0% of the total voting power of
the Capital Stock of the Issuer, and at the time such Person acquired such voting power, no Person and no Persons that are together a group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act or any successor
provision), including any such group acting for the purpose of acquiring, holding or disposing of securities (within the meaning of Rule 13d-5(b)(1) under the Exchange Act), shall have beneficial ownership
(within the meaning of Rule 13d-3 under the Exchange Act, or any successor provision), directly or indirectly, of 50.0% or more of the total voting power of the Voting Stock of such Person.

 “ Participant ” means, with respect to Euroclear or Clearstream, a Person who has an account with Euroclear or Clearstream,
respectively.
 “ Permitted Liens ” means, with respect to any Person:

 (1) pledges or deposits by such Person under workmen’s compensation laws, unemployment insurance, health, disability or
employee benefits, other social security laws or similar legislation or regulations or other insurance-related obligations (including, but not limited to, in respect of deductibles, self-insured retention amounts and premiums and adjustments
thereto) or indemnification obligations of (including obligations in respect of letters of credit or bank guarantees for the benefit of) insurance carriers providing property, casualty or liability insurance, or good faith deposits in connection
with bids, tenders, contracts (other than for the payment of Indebtedness) or leases to which such Person is a party, or deposits to secure public or statutory obligations of such Person or deposits of cash or U.S. government bonds to secure surety
or appeal bonds to which such Person is a party, or deposits as security for contested taxes or import duties or for the payment of rent, in each case incurred in the ordinary course of business;

 (2) landlords’, carriers’, warehousemen’s, materialsmen’s, repairmen’s, construction and
mechanics’ Liens, in each case arising in the ordinary course of business and (i) for sums not yet overdue for a period of more than 60 days or, if more than 60 days overdue, are unfiled and no other action has been taken to enforce such
Liens, (ii) being contested in good faith by appropriate actions or other Liens arising out of judgments or awards against such Person with respect to which such Person shall then be proceeding with an appeal or other proceedings for review if
adequate reserves with respect thereto are maintained on the books of such Person in accordance with GAAP or (iii) the nonpayment of which in the aggregate would not reasonably be expected to have a material adverse effect on the Issuer or its
Restricted Subsidiaries;
 (3) Liens for taxes, assessments or other governmental charges not yet overdue for a period of
more than 30 days or not yet payable or subject to penalties for nonpayment or which are being contested in good faith by appropriate actions, if adequate reserves with respect thereto are maintained on the books of such Person in accordance with
GAAP;

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 (4) Liens in favor of issuers of performance, surety, bid, indemnity,
warranty, release, appeal or similar bonds, instruments or obligations or with respect to regulatory requirements or letters of credit or bankers acceptance issued, and completion guarantees provided for, in each case, issued pursuant to the request
of and for the account of such Person in the ordinary course of its business or consistent with past practice or industry practice;

 (5) survey exceptions, encumbrances, easements or reservations of, or rights of others for, licenses, rights-of-way, servitudes, sewers, electric lines, telegraph, telephone and cable television lines and other similar purposes, or zoning, building codes or other restrictions
(including minor defects or irregularities in title and similar encumbrances) as to the use of real properties or Liens incidental to the conduct of the business of such Person or to the ownership of its properties which were not incurred in
connection with Indebtedness and which do not in the aggregate materially impair their use in the operation of the business of such Person and exceptions on title policies insuring liens granted on Mortgaged Properties (as defined in the Senior
Credit Facilities);
 (6) Liens securing Capitalized Lease Obligations and purchase money obligations (including in respect
of mortgage, industrial revenue bond, industrial development bond and similar financings) and otherwise securing all or any part of the purchase price of property acquired or cost of construction of property or cost of additions, substantial
repairs, alternations or improvements of property, if the Indebtedness and the related Liens are incurred within 18 months of the later of such acquisition of property or completion of construction or addition, repairs, alterations or improvements,
as the case may be;
 (7) Liens existing, or provided for under binding contracts existing, on the Issue Date;

 (8) Liens on property or shares of stock or other assets of a Person at the time such Person becomes a Subsidiary;
 provided , that such Liens are not created or incurred in connection with, or in contemplation of, such other Person becoming such a Subsidiary; provided , further , that such Liens are limited to all or part of the same property
or assets (plus improvements, accessions, proceeds or dividends or distributions in respect thereof and after-acquired property) that secured the obligations to which such Liens relate;

 (9) Liens on property or other assets at the time the Issuer or a Restricted Subsidiary acquired the property or such other
assets, including any acquisition by means of a merger, amalgamation or consolidation with or into the Issuer or any of its Restricted Subsidiaries; provided , that such Liens are not created or incurred in connection with, or in contemplation
of, such acquisition, amalgamation, merger or consolidation; provided , further , that such Liens are limited to all or part of the same property or assets (plus improvements, accessions, proceeds or dividends or distributions in respect
thereof and after acquired-property) that secured the obligations to which such Liens relate;
 (10) Liens securing the
Senior Secured Notes and the related guarantees;
 (11) Liens securing (x) Hedging Obligations and (y) obligations
in respect of Cash Management Services;

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 (12) Liens on specific items of inventory or other goods and proceeds of any
Person securing such Person’s obligations in respect of bankers’ acceptances or letters of credit issued or created for the account of such Person to facilitate the purchase, shipment or storage of such inventory or other goods;

 (13) leases, subleases, licenses or sublicenses (or other agreement under which the Issuer or any Restricted Subsidiary has
granted rights to end users to access and use the Issuer’s or any Restricted Subsidiary’s products, technologies or services) granted to others in the ordinary course of business which do not materially interfere with the ordinary
conduct of the business of the Issuer or any of its Restricted Subsidiaries and the customary rights reserved or vested in any Person by the terms of any lease, sublease, license, sublicense, grant or permit, or to require annual or periodic
payments as a condition to the continuance thereof;
 (14) Liens arising from Uniform Commercial Code (or equivalent
statutes) financing statement filings regarding operating leases, consignments or accounts entered into by the Issuer and its Restricted Subsidiaries in the ordinary course of business or consistent with industry practice or purported Liens
evidenced by the filing of precautionary Uniform Commercial Code (or equivalent statutes) financing statements or similar public filings;

 (15) Liens in favor of the Issuer or any Subsidiary of the Issuer;

 (16) Liens on equipment of the Issuer or any of its Restricted Subsidiaries granted in the ordinary course of business or
consistent with industry practice to the clients of the Issuer or any of its Restricted Subsidiaries;
 (17) Liens on
accounts receivable, Securitization Assets and related assets incurred in connection with a Qualified Securitization Facility;

 (18) Liens to secure any modification, refinancing, refunding, extension, renewal or replacement (or successive modification,
refinancing, refunding, extensions, renewals or replacements) as a whole, or in part, of any Indebtedness secured by any Lien referred to in the foregoing clauses (6), (7), (8) and (9); provided , that (a) such new Lien shall be limited
to all or part of the same property (plus improvements, accessions, proceeds or dividends or distributions in respect thereof and after-acquired property) that secured the original Lien ( plus improvements and accessions on such property) and
proceeds and products thereof, and (b) the Indebtedness secured by such Lien at such time is not increased to any amount greater than the sum of (i) the outstanding principal amount or, if greater, committed amount of the Indebtedness
secured by a Lien under clauses (6), (7), (8) and (9) at the time the original Lien became a Permitted Lien under this Indenture, and (ii) an amount necessary to pay any fees and expenses (including original issue discount, upfront fees or
similar fees) and premiums (including tender premiums and accrued and unpaid interest), related to such refinancing, refunding, extension, renewal or replacement;

 (19) deposits made or other security provided in the ordinary course of business to secure liability to insurance carriers or
self-insurance arrangements;
 (20) Liens securing obligations in an aggregate principal amount at any one time outstanding
not to exceed the greater of (a) $2,000,000,000 and (b) 50% of EBITDA for the most recently ended Test Period;

 -21-

 (21) Liens in favor of customs and revenue authorities arising as a matter
of law to secure payment of customs duties in connection with the importation of goods in the ordinary course of business;

 (22) (i) the prior rights of consignees and their lenders under consignment arrangements entered into in the ordinary course of
business or consistent with industry practice, (ii) Liens arising out of conditional sale, title retention or similar arrangements for the sale of goods in the ordinary course of business or consistent with industry practice and
(iii) Liens arising by operation of law under Article 2 of the Uniform Commercial Code;
 (23) Liens securing judgments
for the payment of money not constituting an Event of Default under Section 6.01(5) hereof;
 (24) Liens in favor of
customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the importation of goods in the ordinary course of business or consistent with industry practice;

 (25) Liens (a) of a collection bank arising under Section 4-208 of the
Uniform Commercial Code on items in the course of collection, (b) attaching to commodity trading accounts or other commodity brokerage accounts incurred in the ordinary course of business, and (c) in favor of banking institutions arising
as a matter of law or under general terms and conditions encumbering deposits (including the right of set-off) and which are within the general parameters customary in the banking industry;

 (26) Liens deemed to exist in connection with Investments in repurchase agreements; provided that such Liens do not
extend to any assets other than those that are the subject of such repurchase agreement;
 (27) Liens encumbering reasonable
customary deposits and margin deposits and similar Liens attaching to commodity trading accounts or other brokerage accounts incurred in the ordinary course of business and not for speculative purposes;

 (28) Liens that are contractual rights of set-off (a) relating to the
establishment of depository relations with banks or other deposit-taking financial institutions and not given in connection with the issuance of Indebtedness, (b) relating to pooled deposit or sweep accounts of the Issuer or any of its
Restricted Subsidiaries to permit satisfaction of overdraft or similar obligations incurred in the ordinary course of business of the Issuer and its Restricted Subsidiaries or consistent with industry practice or (c) relating to purchase orders
and other agreements entered into with customers of the Issuer or any of its Restricted Subsidiaries in the ordinary course of business or consistent with industry practice;

 (29) Liens arising from Personal Property Security Act financing statement filings regarding leases entered into by the Issuer
or any of its Restricted Subsidiaries in the ordinary course of business;
 (30) any encumbrance or restriction (including
put, call arrangements, tag, drag, right of first refusal and similar rights) with respect to capital stock of any joint venture or similar arrangement pursuant to any joint venture or similar agreement;

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 (31) Liens arising out of conditional sale, title retention, consignment or
similar arrangements for the sale or purchase of goods entered into by the Issuer or any Restricted Subsidiary in the ordinary course of business;

 (32) Liens solely on any cash earnest money deposits made by the Issuer or any of its Restricted Subsidiaries in connection
with any letter of intent or purchase agreement;
 (33) ground leases in respect of real property on which facilities owned
or leased by the Issuer or any of its Subsidiaries are located;
 (34) Liens on insurance policies and the proceeds thereof
securing the financing of the premiums with respect thereto;
 (35) Liens on Capital Stock or other securities of an
Unrestricted Subsidiary that secure Indebtedness or other obligations of such Unrestricted Subsidiary;
 (36) Liens on cash
advances in favor of the seller of any property to be acquired in an Investment or other acquisition to be applied against the purchase price for such Investment or other acquisition;

 (37) any interest or title of a lessor, sublessor, licensor or sublicensor or secured by a lessor’s, sublessor’s,
licensor’s or sublicensor’s interest under leases or licenses entered into by the Issuer or any of the Restricted Subsidiaries in the ordinary course of business or consistent with industry practice;

 (38) deposits of cash with the owner or lessor of premises leased and operated by the Issuer or any of its Subsidiaries in the
ordinary course of business of the Issuer and such Subsidiary or consistent with industry practice to secure the performance of the Issuer’s or such Subsidiary’s obligations under the terms of the lease for such premises;

 (39) Liens arising in the ordinary course of business to secure accounts payable or similar trade obligations not constituting
Indebtedness;
 (40) security given to a public utility or any municipality or governmental authority when required by such
utility or authority in connection with the operations of that Person in the ordinary course of business;
 (41) any proxy
agreement relating to IMS Government Solutions, Inc. and its Equity Interests entered into with the Defense Security Service;

 (42) any encumbrance or restriction imposed under any contract for the sale by the Issuer or any of its Restricted Subsidiaries
of the Capital Stock of any Restricted Subsidiary, or any business unit or division of the Issuer or any Restricted Subsidiary;

 (43) Liens securing any Indebtedness incurred under any Secured Revolving Commitments established in compliance with the terms
of this Indenture;
 (44) Liens securing the Notes and Guarantees, if any, of the Notes; and

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 (45) Liens securing obligations in respect of Indebtedness incurred
under any Credit Facility, including any letter of credit facility relating thereto, that do not at any one time exceed $10,425,000,000.

 For purposes of this definition, the term “Indebtedness” shall be deemed to include interest and other obligations payable on and
with respect to such Indebtedness.
 “ Person ” means any individual, corporation, limited liability company, partnership,
joint venture, association, joint stock company, trust, unincorporated organization, government or any agency or political subdivision thereof or any other entity.

 “ Preferred Stock ” means any Equity Interest with preferential rights of payment of dividends or upon liquidation,
dissolution, or winding up.
 “ Principal Personal or Real Property ” means any personal or real property (including, for
the avoidance of doubt, accounts receivable and inventory) other than property that, in the opinion of the Issuer, is not of material importance to the total business conducted by the Issuer and its Subsidiaries, taken as a whole.

 “ Private Placement Legend ” means the legend set forth in Section 2.06(g)(i) hereof to be placed on all Notes issued
under this Indenture, except where otherwise permitted by the provisions of this Indenture.
 “ Public Company Costs ”
means the initial costs relating to establishing compliance with the Sarbanes-Oxley Act of 2002, as amended, and other expenses arising out of or incidental to the Issuer’s or its Restricted Subsidiaries’ initial establishment of
compliance with the obligations of a reporting company, including costs, fees and expenses (including legal, accounting and other professional fees) relating to compliance with provisions of the Securities Act and the Exchange Act.

 “ QIB ” means a “qualified institutional buyer” as defined in Rule 144A.

 “ Qualified Equity Interests ” means any Equity Interests that are not Disqualified Stock.

 “ Qualified Securitization Facility ” means any Securitization Facility (1) constituting a securitization financing
facility that meets the following conditions: (a) the Board of Directors shall have determined in good faith that such Securitization Facility (including financing terms, covenants, termination events and other provisions) is in the aggregate
economically fair and reasonable to the Issuer and the applicable Restricted Subsidiary or Securitization Subsidiary and (b) all sales and/or contributions of Securitization Assets and related assets to the applicable Person or Securitization
Subsidiary are made at fair market value (as determined in good faith by the Issuer) or (2) constituting a receivables financing facility (it being understood that, for the avoidance of doubt, the Receivables Facility is deemed to be a
Qualified Securitization Facility).
 “ Rating Agencies ” means Moody’s and S&P or if Moody’s or S&P
or both shall not make a rating on the Notes publicly available, a nationally recognized statistical rating agency or agencies, as the case may be, selected by the Issuer which shall be substituted for Moody’s or S&P or both, as the case
may be.

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 “ Ratings Decline Period ” means, with respect to any Change of Control,
the period that (1) begins on the earlier of (a) the date of the first public announcement of such Change of Control or of the Issuer’s intention to effect such Change of Control or (b) the occurrence of such Change of Control
and (2) ends on the 60th calendar day following consummation of such Change of Control; provided , however , that such period shall be extended for so long as any Rating Agency rating the Notes as of
the beginning of the Ratings Decline Period has publicly announced during the Ratings Decline Period that the rating of the Notes is under consideration for downgrade by such Rating Agency.

 “ Receivables Facility ” means the receivables facility pursuant to (a) that certain Receivables Financing Agreement,
dated December 5, 2014, among IQVIA RDS Funding LLC, as borrower, IQVIA RDS Inc., as initial servicer, PNC Bank, N.A., as administrative agent and lender, and the additional persons from time to time party thereto as lenders and (b) that
certain Purchase and Sale Agreement, dated December 5, 2014, as amended, among IQVIA RDS Inc., as originator and initial servicer, IQVIA CSMS US Inc., as originator, and IQVIA RDS Funding LLC, as buyer, in each case, as amended, modified or
supplemented from time to time so long as such amendments, modifications and supplements are either, taken as a whole, not materially adverse to the interests of the Holders as determined in good faith by the Issuer or consented to by the
administrative agent under the Senior Credit Facilities, and any extension thereof to receivables of the Issuer and any of its Subsidiaries.

 “ Record Date ” for the interest payable on any applicable Interest Payment Date means the close of business on the Clearing
System Business Day immediately preceding such Interest Payment Date.
 “ Registered Equivalent Notes ” means, with
respect to any notes originally issued in an offering pursuant to Rule 144A under the Securities Act or other private placement transaction under the Securities Act, substantially identical notes (having the same guarantees) issued in a dollar-for-dollar exchange therefor pursuant to an exchange offer registered with the SEC.

 “ Regulation S ” means Regulation S promulgated under the Securities Act.

 “ Regulation S Global Note ” means a Regulation S Temporary Global Note or Regulation S Permanent Global Note, as applicable.

 “ Regulation S Permanent Global Note ” means a permanent Global Note in the form of Exhibit A attached hereto,
with such applicable legends as are provided herein, and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its
nominee for the accounts of Euroclear and Clearstream issued in a denomination equal to the outstanding principal amount of the Regulation S Temporary Global Note upon expiration of the applicable Restricted Period.

 “ Regulation S Temporary Global Note ” means a temporary Global Note in the form of Exhibit A attached hereto, bearing
the Global Note Legend, the Private Placement Legend and having the “Schedule of Exchanges of Interests in the Global Note” attached thereto, deposited with the Notes Custodian and registered in the name of the Common Depositary or its
nominee for the accounts of Euroclear and Clearstream issued in a denomination equal to the outstanding principal amount of the Notes initially sold in reliance on Rule 903.

 “ Regulation S Temporary Global Note Legend ” means the legend set forth in Section 2.06(g)(iii) hereof.

 “ Responsible Officer ” means, when used with respect to the Trustee, any officer within the corporate trust department of
the Trustee, including any director, vice president, assistant vice president, any trust officer or assistant trust officer or any other officer of the Trustee who customarily performs functions similar to those performed by the Persons who at the
time shall be such officers, respectively, or to whom any corporate trust matter is referred because of such Person’s knowledge of and familiarity with the particular subject and, in each case, who shall have direct responsibility for the
administration of this Indenture.

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 “ Restricted Period ” means, in respect of any Note issued pursuant to
Regulation S, the 40-day distribution compliance period as defined in Regulation S applicable to such Note.

 “ Restricted Subsidiary ” means, at any time, any direct or indirect Subsidiary of the Issuer (including any Foreign
Subsidiary) that is not then an Unrestricted Subsidiary; provided , that upon the occurrence of an Unrestricted Subsidiary ceasing to be an Unrestricted Subsidiary, such Subsidiary shall be included in the definition of “Restricted
Subsidiary.”
 “ Rule 144 ” means Rule 144 promulgated under the Securities Act.

 “ Rule 144A ” means Rule 144A promulgated under the Securities Act.

 “ Rule 903 ” means Rule 903 promulgated under the Securities Act.

 “ Rule 904 ” means Rule 904 promulgated under the Securities Act.

 “ S&P ” means S&P Global Ratings, a division of S&P Global Inc., and any successor to its rating agency business.

 “ Sale and Lease-Back Transaction ” means any arrangement providing for the leasing for a period of more than three
years by the Issuer or any of its Restricted Subsidiaries of any real or tangible personal property, which property has been or is to be sold or transferred by the Issuer or such Restricted Subsidiary to a third Person in contemplation of such
leasing.
 “ SEC ” means the U.S. Securities and Exchange Commission.

 “ Secured Indebtedness ” means any Indebtedness of the Issuer or any of its Restricted Subsidiaries secured by a Lien.

 “ Secured Revolving Commitments ” means any commitments to make loans constituting Secured Indebtedness on a revolving basis
to the Issuer or any of its Restricted Subsidiaries by any Person other than the Issuer or any of its Restricted Subsidiaries.

 “ Securities Act ” means the Securities Act of 1933, as amended, and the rules and regulations of the SEC promulgated
thereunder.
 “ Securitization Assets ” means (a) the accounts receivable, royalty or other revenue streams and other
rights to payment and other assets related thereto subject to a Qualified Securitization Facility and the proceeds thereof and (b) contract rights, lockbox accounts and records with respect to such accounts receivable and any other assets
customarily transferred together with accounts receivable in a securitization financing.
 “ Securitization Facility ”
means any of one or more receivables or securitization financing facilities, as amended, supplemented, modified, extended, renewed, restated or refunded from time to time, the Obligations of which are
 non-recourse (except for customary representations, warranties, covenants and indemnities made in connection with such facilities) to the Issuer or any of its Restricted Subsidiaries (other than a
Securitization Subsidiary) pursuant to which the Issuer or any of its Restricted Subsidiaries sells or grants a security interest in its accounts receivable or Securitization Assets or assets related thereto to either (a) a Person that is not a
Restricted Subsidiary or (b) a Securitization Subsidiary that in turn sells its accounts receivable to a Person that is not a Restricted Subsidiary.

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 “ Securitization Subsidiary ” means any Subsidiary formed for the purpose
of, and that solely engages only in one or more Qualified Securitization Facilities and other activities reasonably related thereto.

 “ Senior Credit Facilities ” means, collectively, the senior secured term loan facilities and the senior secured revolving
credit facilities under that certain Fifth Amended and Restated Credit Agreement, dated as of August 25, 2021, among the Issuer, Holdings, IQVIA RDS Inc., a North Carolina corporation, the Restricted Subsidiaries party thereto, Bank of America,
N.A., as the administrative agent, and the lenders and other entities party thereto, including any guarantees, collateral documents, instruments and agreements executed in connection therewith, and any amendments, supplements, modifications,
extensions, renewals, restatements, refundings, refinancings or replacements thereof and any one or more indentures or credit facilities or commercial paper facilities with banks or other institutional lenders, or investors, whether or not secured,
that replace, refund, supplement or refinance any part of the loans, notes, other credit facilities or commitments thereunder, including any such replacement, refunding or refinancing facility or indenture that increases the amount borrowable
thereunder or alters the maturity thereof or adds Restricted Subsidiaries as additional borrowers or guarantors thereunder and whether by the same or any other agent, trustee, lender or group of lenders or holders.

 “ Senior Indebtedness ” means:

 (1) all Indebtedness of the Issuer or any Guarantor outstanding under the Senior Credit Facilities, the Existing Senior Notes
and the Notes and related Guarantees (including interest accruing on or after the filing of any petition in bankruptcy or similar proceeding or for reorganization of the Issuer or any Guarantor (at the rate provided for in the documentation with
respect thereto, regardless of whether or not a claim for post-filing interest is allowed in such proceedings)), and any and all other fees, expense reimbursement obligations, indemnification amounts, penalties, and other amounts (whether existing
on the Issue Date or thereafter created or incurred) and all obligations of the Issuer or any Guarantor to reimburse any bank or other Person in respect of amounts paid under letters of credit, acceptances or other similar instruments;

 (2) all (x) Hedging Obligations (and guarantees thereof) and (y) obligations in respect of Cash Management Services
(and guarantees thereof) owing to a lender under the Senior Credit Facilities or any Affiliate of such lender (or any Person that was a lender or an Affiliate of such lender at the time the applicable agreement giving rise to such Hedging Obligation
was entered into); provided that such Hedging Obligations and obligations in respect of Cash Management Services, as the case may be, are permitted to be incurred under the terms of this Indenture;

 (3) any other Indebtedness of the Issuer or any Guarantor permitted to be incurred under the terms of this Indenture, unless
the instrument under which such Indebtedness is incurred expressly provides that it is subordinated in right of payment to the Notes or any related Guarantee; and

 (4) all Obligations with respect to the items listed in the preceding clauses (1), (2) and (3);

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 provided , that Senior Indebtedness shall not include:

 (a) any obligation of such Person to the Issuer or any of its Subsidiaries;

 (b) any liability for federal, state, local or other taxes owed or owing by such Person;

 (c) any accounts payable or other liability to trade creditors arising in the ordinary course of business or consistent with
industry practice;
 (d) any Indebtedness or other Obligation of such Person which is subordinate or junior in any respect
to any other Indebtedness or other Obligation of such Person; or
 (e) that portion of any Indebtedness which at the time of
incurrence is incurred in violation of this Indenture.
 “ Senior 1.750% Notes ” means 550,000,000 in aggregate
principal amount of the Issuer’s senior unsecured notes due 2026.
 “ Senior 1.750%/2.250% Notes Indenture ” means
the indenture dated March 3, 2021, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or
modified from time to time.
 “ Senior 2.250% Notes due 2028 ” means 720,000,000 in aggregate principal amount of
the Issuer’s senior unsecured notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 2.250% Notes due 2028 Indenture in exchange for the initial unregistered senior unsecured
notes.
 “ Senior 2.250% Notes due 2028 Indenture ” means the indenture dated August 13, 2019, by and among the
Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time.

 “ Senior 2.250% Notes due 2029 ” means 900,000,000 in aggregate principal amount of the Issuer’s senior unsecured
notes due 2029 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 1.750%/2.250% Notes Indenture in exchange for the initial unregistered senior unsecured notes.

 “ Senior 2.875% Notes due 2028 ” means 711,000,000 in aggregate principal amount of the Issuer’s senior unsecured
notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 2.875% Notes due 2028 Indenture in exchange for the initial unregistered senior unsecured notes.

 “ Senior 2.875% Notes due 2028 Indenture ” means the indenture dated June 24, 2020, by and among the Issuer, the
guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time.

 “ Senior 3.250% Notes ” means 1,425,000,000 in aggregate principal amount of the Issuer’s senior unsecured notes
due 2025.

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 “ Senior 4.875% Notes ” means $800,000,000 in aggregate principal amount of
the Issuer’s senior unsecured notes due 2023.
 “ Senior 5.000% Notes due 2026 ” means $1,050,000,000 in aggregate
principal amount of the Issuer’s senior unsecured notes due 2026 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 5.000% Notes due 2026 Indenture in exchange for the initial
unregistered senior unsecured notes.
 “ Senior 5.000% Notes due 2026 Indenture ” means the indenture dated
September 28, 2016, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time
to time.
 “ Senior 5.000% Notes due 2027 ” means $1,100,000,000 in aggregate principal amount of the Issuer’s
senior unsecured notes due 2027 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 5.000% Notes due 2027 Indenture in exchange for the initial unregistered senior unsecured notes.

 “ Senior 5.000% Notes due 2027 Indenture ” means the indenture dated May 10, 2019, by and among the Issuer, the
guarantors party thereto and U.S. Bank Trust Company, National Association (as successor in interest to U.S. Bank National Association), as trustee, as amended, supplemented or modified from time to time.

 “ Senior 6.250% Notes due 2032 ” means the $2,000,000,000 in aggregate principal amount of the Issuer’s senior
unsecured notes due 2032 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 6.250% Notes due 2032 Indenture in exchange for the initial unregistered senior unsecured notes.

 “ Senior 6.250% Notes due 2032 Indenture ” means the indenture dated June 4, 2025, by and among the Issuer, the
guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee, as amended, supplemented or modified from time to time.

 “ Senior 6.500% Notes due 2030 ” means the $500,000,000 in aggregate principal amount of the Issuer’s senior unsecured
notes due 2030 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior 6.500% Notes due 2030 Indenture in exchange for the initial unregistered senior unsecured notes.

 “ Senior 6.500% Notes due 2030 Indenture ” means the indenture dated May 23, 2023, by and among the Issuer, the
guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee, as amended, supplemented or modified from time to time.

 “ Senior Secured 5.700% Notes due 2028 ” means the $750,000,000 in aggregate principal amount of the Issuer’s 5.700%
senior secured notes due 2028 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior Secured 5.700% Notes due 2028 Indenture in exchange for the initial unregistered senior secured notes.

 “ Senior Secured 5.700% Notes due 2028 Indenture ” means the amended and restated indenture, dated December 19, 2023, by
and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee and collateral agent, as amended, supplemented or modified from time to time.

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 “ Senior Secured 6.250% Notes due 2029 ” means the $1,250,000,000 in
aggregate principal amount of the Issuer’s 6.250% senior secured notes due 2029 and any Registered Equivalent Notes having substantially identical terms and issued pursuant to the Senior Secured 6.250% Notes due 2029 Indenture in exchange for
the initial unregistered senior secured notes.
 “ Senior Secured 6.250% Notes due 2029 Indenture ” means the amended and
restated indenture, dated December 19, 2023, by and among the Issuer, the guarantors party thereto and U.S. Bank Trust Company, National Association, as trustee and collateral agent, as amended, supplemented or modified from time to time.

 “ Senior Secured Net Leverage Ratio ” means, with respect to any Test Period, the ratio of (a) Consolidated Total Debt
(other than any Indebtedness of a Restricted Subsidiary which is not a Guarantor which is not secured by any assets of the Issuer or a Guarantor) outstanding on the last day of such Test Period that is secured by a Lien on any property of the Issuer
or any Restricted Subsidiary (other than property or assets held in a defeasance or similar trust or arrangement for the benefit of the Indebtedness secured thereby) minus the aggregate amount of cash and cash equivalents included in the
consolidated balance sheet of the Issuer as of such date, excluding cash and cash equivalents which are listed as “Restricted” on such balance sheet, to (b) EBITDA of the Issuer for such Test Period. In the event that the
Issuer or any Restricted Subsidiary incurs, assumes, guarantees, redeems, repays, retires or extinguishes any Secured Indebtedness (other than Secured Indebtedness incurred under any revolving credit facility in the ordinary course of business for
working capital purposes or any repayment of such Indebtedness in the ordinary course of business) subsequent to the commencement of the period for which the Senior Secured Net Leverage Ratio is being calculated but prior to or simultaneously with
the event for which such calculation is made, then the Senior Secured Net Leverage Ratio, as applicable, shall be calculated giving pro forma effect to such incurrence, assumption, guarantee, redemption, repayment, retirement or
extinguishment of Secured Indebtedness, in each case, as if the same had occurred on the last day of the applicable Test Period, and if the Senior Secured Net Leverage Ratio is being calculated in connection with establishing any Secured Revolving
Commitments, then such calculation shall be made giving pro forma effect to the incurrence of the entire committed amount of Secured Indebtedness under such Secured Revolving Commitments.

 For purposes of making the computation referred to above, any Specified Transaction that has been made by the Issuer or any of its Restricted
Subsidiaries during any Test Period or subsequent to such Test Period and on or prior to or simultaneously with the event for which the calculation of the Senior Secured Net Leverage Ratio is made shall be calculated on a pro
 forma basis assuming that all such Specified Transactions (and the change in EBITDA resulting therefrom) had occurred on the first day of the Test Period. If since the beginning of such Test Period any Person that subsequently became
a Restricted Subsidiary or was merged, amalgamated or consolidated with or into the Issuer or any of its Restricted Subsidiaries since the beginning of such Test Period shall have made any Specified Transaction that would have required adjustment
pursuant to this definition, then EBITDA shall be calculated giving pro forma effect thereto for such Test Period as if such Specified Transaction had occurred at the beginning of the applicable Test Period.

 For purposes of this definition, whenever pro forma effect is to be given to any Specified Transaction, the pro
 forma calculations shall be made in good faith by a Financial Officer of the Issuer and may include, for the avoidance of doubt, the amount of “run-rate” cost savings, synergies and
operating expense reductions resulting from or related to any such Specified Transaction which is being given pro forma effect that have been realized or are expected to be realized and for which the actions necessary to
realize such cost savings, operating expense reductions and synergies are taken, committed to be taken or with respect to which substantial steps have been taken or are expected to be taken no later than 24 months after the date of any such
Specified Transaction (in each case as though such cost savings

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and synergies had been realized on the first day of the applicable period and as if such cost savings and synergies were realized for the entirety of such period). For the purposes of this
Indenture, “ run-rate ” means the full recurring benefit for a period that is associated with any action taken, committed to be taken, or with respect to which substantial steps have been
taken or are expected to be taken (including any savings expected to result from the elimination of a public target’s compliance costs with public company requirements), net of the amount of actual benefits realized during such period from
such actions.
 For purposes of this definition, the amount of any Secured Indebtedness in a currency other than U.S. dollars will be
converted to U.S. dollars based on the average exchange rate for such currency for the most recent twelve month period immediately prior to the date of determination in a manner consistent with that used in calculating EBITDA for the applicable
period (after giving effect to the currency translation effects, determined in accordance with GAAP, of hedging arrangements for currency exchange risks with respect to the applicable currency in effect on the date of determination of the applicable
amount of such Indebtedness).
 “ Senior Secured Notes ” means, collectively, the Senior Secured 5.700% Notes due 2028 and
Senior Secured 6.250% Notes due 2029.
 “ Significant Subsidiary ” means any Restricted Subsidiary that would be a
“significant subsidiary” as defined in Article 1, Rule 1-02 of Regulation S-X of the SEC, as such regulation is in effect on the Issue Date; provided
that notwithstanding the foregoing, in no event will any Securitization Subsidiary be considered a Significant Subsidiary for purposes of clauses (4), (5), (6), (7) or (8) under Section 6.01.

 “ Specified Legal Expenses ” means, to the extent not constituting an extraordinary,
 non-recurring or unusual loss, charge or expense, all attorneys’ and experts’ fees and expenses and all other costs, liabilities (including all damages, penalties, fines and indemnification and
settlement payments) and expenses paid or payable in connection with any threatened, pending, completed or future claim, demand, action, suit, proceeding, inquiry or investigation (whether civil, criminal, administrative, governmental or
investigative) either (i) arising from, or related to, facts and circumstances existing on or prior to the Issue Date or (ii) arising out of or related to antitrust, Federal Trade Commission or Department of Justice proceedings or
securities law.
 “ Specified Transaction ” means (i) solely for the purposes of determining the applicable cash
balance, any contribution of capital, including as a result of an Equity Offering, to the Issuer, in each case, in connection with an acquisition or Investment, (ii) any designation of operations or assets of the Issuer or a Restricted
Subsidiary as discontinued operations (as defined under GAAP) (other than held-for-sale discontinued operations until actually disposed of), (iii) any Investment
that results in a Person becoming a Restricted Subsidiary, (iv) any designation of a Subsidiary as a Restricted Subsidiary or an Unrestricted Subsidiary in compliance with this Indenture, (v) any purchase or other acquisition of a business
of any Person, of assets constituting a business unit, line of business or division of any Person, or (vi) any disposition (x) that results in a Restricted Subsidiary ceasing to be a Subsidiary of the Issuer or (y) of a business,
business unit, line of business or division of the Issuer or a Restricted Subsidiary, in each case whether by merger, amalgamation, consolidation or otherwise.

 “ Subordinated Indebtedness ” means, with respect to the Notes,

 (1) any Indebtedness of the Issuer which is by its terms subordinated in right of payment to the Notes, and

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 (2) any Indebtedness of any Guarantor which is by its terms subordinated in
right of payment to the Guarantee of such entity of the Notes.
 “ Subsidiary ” means, with respect to any
Person:
 (1) any corporation, association, or other business entity (other than a partnership, joint venture, limited
liability company or similar entity) of which more than 50.0% of the total voting power of shares of Capital Stock entitled (without regard to the occurrence of any contingency) to vote in the election of directors, members of management or trustees
thereof is at the time of determination owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof; and

 (2) any partnership, joint venture, limited liability company or similar entity of which:

 (a) more than 50.0% of the capital accounts, distribution rights, total equity and voting interests or general or limited
partnership interests, as applicable, are owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof whether in the form of membership, general, special or limited
partnership or otherwise, and
 (b) such Person or any Restricted Subsidiary of such Person is a controlling general partner
or otherwise controls such entity.
 “ Test Period ” means the Issuer’s most recently ended four fiscal quarters for
which internal financial statements are available (as determined in good faith by the Issuer).
 “ TISE ” means The
International Stock Exchange.
 “ TISEAL ” means The International Stock Exchange Authority Limited.

 “ Trustee ” means U.S. Bank Trust Company, National Association, in its capacity as trustee, until a successor replaces it in
accordance with the applicable provisions of this Indenture and thereafter means the successor serving hereunder.
 “ Uniform
Commercial Code ” means the Uniform Commercial Code or any successor provision thereof as the same may from time to time be in effect in the State of New York.

 “ Unrestricted Subsidiary ” means (a) any Subsidiary of the Issuer which at the time of determination is designated as
an “Unrestricted Subsidiary” in any Credit Facility (including the Senior Credit Facilities), whether on or subsequent to the Issue Date, and (b) any Subsidiary of an Unrestricted Subsidiary.

 “ U.S. Person ” means a U.S. person as defined in Rule 902(k) under the Securities Act.

 “ Voting Stock ” of any Person as of any date means the Capital Stock of such Person that is at the time entitled to vote in
the election of the Board of Directors of such Person.
 “ Wholly-Owned Subsidiary ” of any Person means a Subsidiary of
such Person, 100.0% of the outstanding Equity Interests of which (other than directors’ qualifying shares and shares of Capital Stock of Foreign Subsidiaries issued to foreign nationals as required under applicable law) shall at the time be
owned by such Person and/or by one or more Wholly-Owned Subsidiaries of such Person.

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 SECTION 1.02. Other Definitions.

 Term

 Defined in Section

 “Applicable Premium Deficit”

 8.04

 “Authentication Order”

 2.02

 “Change of Control Offer”

 4.07(a)

 “Change of Control Payment”

 4.07(a)

 “Change of Control Payment Date”

 4.07(a)(2)

 “Covenant Defeasance”

 8.03

 “Equity Offering Redemption Amount”

 3.07

 “Event of Default”

 6.01

 “Initial Notes”

 Recitals

 “LCT Election”

 1.05

 “Legal Defeasance”

 8.02

 “Note Register”

 2.03

 “Notes”

 Recitals

 “Paying Agent”

 2.03

 “Redemption Date”

 3.01

 “Registrar”

 2.03

 “Transfer Agent”

 2.03

 SECTION 1.03. Rules of Construction . Unless the context otherwise requires:

 (a) a term has the meaning assigned to it;

 (b) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP;

 (c) “or” is not exclusive;

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 (d) the words “including,” “includes” and similar
words shall be deemed to be followed by without limitation;
 (e) words in the singular include the plural, and in the
plural include the singular;
 (f) “will” shall be interpreted to express a command;

 (g) provisions apply to successive events and transactions;

 (h) references to sections of, or rules under, the Securities Act or the Exchange Act shall be deemed to include substitute,
replacement or successor sections or rules adopted by the SEC from time to time;
 (i) unless the context otherwise
requires, any reference to an “Article,” “Section” or “clause” refers to an Article, Section or clause, as the case may be, of this Indenture;

 (j) the words “herein,” “hereof” and “hereunder” and other words of similar import refer to
this Indenture as a whole and not any particular Article, Section, clause or other subdivision;
 (k) the principal amount
of any Preferred Stock at any time shall be (i) the maximum liquidation value of such Preferred Stock at such time or (ii) the maximum mandatory redemption or mandatory repurchase price with respect to such Preferred Stock at such time,
whichever is greater;
 (l) words used herein implying any gender shall apply to both genders;

 (m) in the computation of periods of time from a specified date to a later specified date, the word “from” means
“from and including”; the words “to” and “until” each mean “to but excluding”; and the word “through” means “to and including”;

 (n) the principal amount of any non-interest bearing Indebtedness or other discount
security constituting Indebtedness at any date shall be the principal amount thereof that would be shown on a balance sheet of the Issuer dated such date prepared in accordance with GAAP; and

 (o) unless otherwise specifically indicated, the term “consolidated” with respect to any Person means such Person
consolidated with its Restricted Subsidiaries and excludes any Unrestricted Subsidiary as if such Unrestricte…

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